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A multicenter comparison of [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

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dc.contributor.author류철형-
dc.contributor.author조한나-
dc.date.accessioned2021-09-29T02:19:16Z-
dc.date.available2021-09-29T02:19:16Z-
dc.date.issued2021-07-
dc.identifier.issn1619-7070-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184827-
dc.description.abstractPurpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer's disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926-0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSpringer-Verlag Berlin-
dc.relation.isPartOfEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlzheimer Disease* / diagnostic imaging-
dc.subject.MESHCarbolines-
dc.subject.MESHCognitive Dysfunction*-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHHumans-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHtau Proteins-
dc.titleA multicenter comparison of [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorAntoine Leuzy-
dc.contributor.googleauthorTharick A Pascoal-
dc.contributor.googleauthorOlof Strandberg-
dc.contributor.googleauthorPhilip Insel-
dc.contributor.googleauthorRuben Smith-
dc.contributor.googleauthorNiklas Mattsson-Carlgren-
dc.contributor.googleauthorAndréa L Benedet-
dc.contributor.googleauthorHannah Cho-
dc.contributor.googleauthorChul H Lyoo-
dc.contributor.googleauthorRenaud La Joie-
dc.contributor.googleauthorGil D Rabinovici-
dc.contributor.googleauthorRik Ossenkoppele-
dc.contributor.googleauthorPedro Rosa-Neto-
dc.contributor.googleauthorOskar Hansson-
dc.identifier.doi10.1007/s00259-021-05401-4-
dc.contributor.localIdA01333-
dc.contributor.localIdA03920-
dc.relation.journalcodeJ00833-
dc.identifier.eissn1619-7089-
dc.identifier.pmid34041562-
dc.subject.keywordPET-
dc.subject.keywordTau-
dc.subject.keyword[18F]Flortaucipir-
dc.subject.keyword[18F]MK6240-
dc.subject.keyword[18F]RO948-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthor류철형-
dc.contributor.affiliatedAuthor조한나-
dc.citation.volume48-
dc.citation.number7-
dc.citation.startPage2295-
dc.citation.endPage2305-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.48(7) : 2295-2305, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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