Cited 33 times in
A multicenter comparison of [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 조한나 | - |
dc.date.accessioned | 2021-09-29T02:19:16Z | - |
dc.date.available | 2021-09-29T02:19:16Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184827 | - |
dc.description.abstract | Purpose: This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau positron emission tomography (PET) tracers for differential diagnosis of Alzheimer's disease (AD) dementia vs either cognitively unimpaired (CU) individuals or non-AD neurodegenerative diseases. Methods: A total of 1755 participants underwent tau PET using either [18F]flortaucipir (n = 975), [18F]RO948 (n = 493), or [18F]MK6240 (n = 287). SUVR values were calculated across four theory-driven ROIs and several tracer-specific data-driven (hierarchical clustering) regions of interest (ROIs). Diagnostic performance and cut-offs for ROIs were determined using receiver operating characteristic analyses and the Youden index, respectively. Results: Comparable diagnostic performance (area under the receiver operating characteristic curve [AUC]) was observed between theory- and data-driven ROIs. The theory-defined temporal meta-ROI generally performed very well for all three tracers (AUCs: 0.926-0.996). An SUVR value of approximately 1.35 was a common threshold when using this ROI. Conclusion: The temporal meta-ROI can be used for differential diagnosis of dementia patients with [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR. This ROI/SUVR cut-off can also be applied across tracers to define tau positivity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Berlin | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alzheimer Disease* / diagnostic imaging | - |
dc.subject.MESH | Carbolines | - |
dc.subject.MESH | Cognitive Dysfunction* | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | tau Proteins | - |
dc.title | A multicenter comparison of [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Antoine Leuzy | - |
dc.contributor.googleauthor | Tharick A Pascoal | - |
dc.contributor.googleauthor | Olof Strandberg | - |
dc.contributor.googleauthor | Philip Insel | - |
dc.contributor.googleauthor | Ruben Smith | - |
dc.contributor.googleauthor | Niklas Mattsson-Carlgren | - |
dc.contributor.googleauthor | Andréa L Benedet | - |
dc.contributor.googleauthor | Hannah Cho | - |
dc.contributor.googleauthor | Chul H Lyoo | - |
dc.contributor.googleauthor | Renaud La Joie | - |
dc.contributor.googleauthor | Gil D Rabinovici | - |
dc.contributor.googleauthor | Rik Ossenkoppele | - |
dc.contributor.googleauthor | Pedro Rosa-Neto | - |
dc.contributor.googleauthor | Oskar Hansson | - |
dc.identifier.doi | 10.1007/s00259-021-05401-4 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A03920 | - |
dc.relation.journalcode | J00833 | - |
dc.identifier.eissn | 1619-7089 | - |
dc.identifier.pmid | 34041562 | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | Tau | - |
dc.subject.keyword | [18F]Flortaucipir | - |
dc.subject.keyword | [18F]MK6240 | - |
dc.subject.keyword | [18F]RO948 | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | 류철형 | - |
dc.contributor.affiliatedAuthor | 조한나 | - |
dc.citation.volume | 48 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2295 | - |
dc.citation.endPage | 2305 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.48(7) : 2295-2305, 2021-07 | - |
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