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Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer

Authors
 Nam Hee Kim  ;  Sang Hyun Song  ;  Yun Hee Choi  ;  Kyu Ho Hwang  ;  Jun Seop Yun  ;  Hyeeun Song  ;  So Young Cha  ;  Sue Bean Cho  ;  Inhan Lee  ;  Hyun Sil Kim  ;  Jong In Yook 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(17) : 9589, 2021-09 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Issue Date
2021-09
Keywords
Snail ; ZEB1 ; ceRNA ; colorectal cancer ; epithelial mesenchymal transition ; therapeutic resistance
Abstract
The epithelial-mesenchymal transition (EMT) comprises an important biological mechanism not only for cancer progression but also in the therapeutic resistance of cancer cells. While the importance of the protein abundance of EMT-inducers, such as Snail (SNAI1) and Zeb1 (ZEB1), during EMT progression is clear, the reciprocal interactions between the untranslated regions (UTRs) of EMT-inducers via a competing endogenous RNA (ceRNA) network have received little attention. In this study, we found a synchronized transcript abundance of Snail and Zeb1 mediated by a non-coding RNA network in colorectal cancer (CRC). Importantly, the trans-regulatory ceRNA network in the UTRs of EMT inducers is mediated by competition between tumor suppressive miRNA-34 (miR-34) and miRNA-200 (miR-200). Furthermore, the ceRNA network consisting of the UTRs of EMT inducers and tumor suppressive miRs is functional in the EMT phenotype and therapeutic resistance of colon cancer. In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer. These results indicate that the ceRNA networks regulated by the reciprocal interaction between EMT gene UTRs and tumor suppressive miRs are functional in CRC progression and therapeutic resistance.
Files in This Item:
T202103790.pdf Download
DOI
10.3390/ijms22179589
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cha, So Young(차소영) ORCID logo https://orcid.org/0000-0002-2810-3883
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184825
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