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Neural Substrates of Aphasia in Acute Left Hemispheric Stroke Using Voxel-Based Lesion-symptom Brain Mapping

 Eun Ji Park  ;  Yong Wook Kim  ;  Hyo Suk Nam  ;  Hyo Seon Choi  ;  Deog Young Kim 
 Brain & Neurorehabilitation, Vol.14(2) : e14, 2021-07 
Journal Title
Brain & Neurorehabilitation
Issue Date
Stroke ; Aphasia ; Brain Mapping ; Topographic Brain Mapping
It is unclear how these brain lesions fit into the language processing in acute stroke. In this study, we aimed to investigate the neuroanatomical lesion related to language processing in acute stage of stroke patients using voxel-based lesion-symptom mapping (VLSM). 73 acute first-ever post-stroke patients were enrolled in this retrospective study, who had undertaken brain magnetic resonance imaging (MRI) and Korean version of the Western Aphasia Test within 1 month from onset. Each voxel was compared with aphasia quotient and subtest scores as dependent variables using VLSM. The aphasia group showed significantly much more involvement of extra-nuclear area, insula, inferior frontal gyrus and superior temporal gyrus compared to non-aphasia group. The deficit of spontaneous speech domain was associated with the inferior parietal lobule, inferior and middle frontal gyrus and insula. The insular cortex, inferior parietal lobule, inferior frontal gyrus, middle frontal gyrus and superior temporal gyrus were related to deficit of comprehension. The inferior parietal lobule, insula, precentral gyrus, inferior frontal gyrus were related to the deficit of repetition. The deficit of naming was related to inferior parietal lobule, insula and inferior frontal gyrus. In conclusion, VLSM from early MRI imaging study after stroke may be useful to understand the language process network and establish early rehabilitation strategies after stroke.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
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