Cited 2 times in
Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김진성 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 천재희 | - |
dc.contributor.author | 함원식 | - |
dc.date.accessioned | 2021-09-29T01:41:56Z | - |
dc.date.available | 2021-09-29T01:41:56Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184502 | - |
dc.description.abstract | Purpose: Adjuvant radiotherapy (RT) has been performed to reduce locoregional failure (LRF) following radical cystectomy for locally advanced bladder cancer; however, its efficacy has not been well established. We analyzed the locoregional recurrence patterns of post-radical cystectomy to identify patients who could benefit from adjuvant RT and determine the optimal target volume. Materials and methods: We retrospectively reviewed 160 patients with stage ≥ pT3 bladder cancer who were treated with radical cystectomy between January 2006 and December 2015. The impact of pathologic findings, including the stage, lympho-vascular invasion, perineural invasion, margin status, nodal involvement, and the number of nodes removed on failure patterns, was assessed. Results: Median follow-up period was 27.7 months. LRF was observed in 55 patients (34.3%), 12 of whom presented with synchronous local and regional failures as the first failure. The most common failure pattern was distant metastasis (40%). Among LRFs, the most common recurrence site was the cystectomy bed (15.6%). Patients with positive resection margins had a significantly higher recurrence rate compared to those without (28% vs. 10%, p=0.004). The pelvic nodal recurrence rate was < 5% in pN0 patients; the rate of recurrence in the external and common iliac nodes was 12.5% in pN+ patients. The rate of recurrence in the common iliac nodes was significantly higher in pN2-3 patients than in pN0-1 patients (15.2% vs. 4.4%, p=0.04). Conclusion: Pelvic RT could be beneficial especially for those with positive resection margins or nodal involvement after radical cystectomy. Radiation fields should be optimized based on the patient-specific risk factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cystectomy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasm Recurrence, Local / epidemiology | - |
dc.subject.MESH | Radiation Oncologists | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Urinary Bladder Neoplasms* / radiotherapy | - |
dc.subject.MESH | Urinary Bladder Neoplasms* / surgery | - |
dc.title | Patterns of Locoregional Recurrence after Radical Cystectomy for Stage T3-4 Bladder Cancer: A Radiation Oncologist's Point of View | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Hyun Ju Kim | - |
dc.contributor.googleauthor | Jaehee Chun | - |
dc.contributor.googleauthor | Tae Hyung Kim | - |
dc.contributor.googleauthor | Gowoon Yang | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Jin Sung Kim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.identifier.doi | 10.3349/ymj.2021.62.7.569 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A04548 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 34164953 | - |
dc.subject.keyword | Urinary bladder neoplasms | - |
dc.subject.keyword | adjuvant radiotherapy | - |
dc.subject.keyword | cystectomy | - |
dc.subject.keyword | recurrence | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김진성 | - |
dc.contributor.affiliatedAuthor | 신상준 | - |
dc.contributor.affiliatedAuthor | 양재문 | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.contributor.affiliatedAuthor | 함원식 | - |
dc.citation.volume | 62 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 569 | - |
dc.citation.endPage | 576 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.62(7) : 569-576, 2021-07 | - |
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