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Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients

Authors
 Sung Min Ko  ;  Janghee Lee  ;  Soong June Bae  ;  Su Jung Baik  ;  Junghwan Ji  ;  Dooreh Kim  ;  Sung Gwe Ahn  ;  Joon Jeong 
Citation
 BRITISH JOURNAL OF CANCER, Vol.125(1) : 119-125, 2021-07 
Journal Title
BRITISH JOURNAL OF CANCER
ISSN
 0007-0920 
Issue Date
2021-07
Abstract
Background: Our study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females. Additionally, we determined the prognostic value of these factors in breast cancer.

Methods: We retrospectively identified 1225 primary invasive breast cancer patients and 35,991 healthy females. Factors including BMI and complete blood count associated with disease-free survival (DFS) were assessed using a multi-variable Cox proportional hazard model.

Results: BMI and ALC were positively correlated in breast cancer patients and healthy females (both P < 0.001). In multi-variable analysis, overweight or obese participants had worse DFS (hazards ratio [HR], 1.98; 95% confidence interval [CI], 1.34-2.92; P = 0.001) than underweight or normal-weight individuals, but patients with high ALC had better DFS than those with low ALC (HR, 0.43; 95% CI, 0.29-0.65; P < 0.001). After risk stratification according to BMI/ALC, high-risk patients with high BMI/low ALC had worse DFS than others (HR, 2.48; 95% CI, 1.70-3.62; P < 0.001).

Conclusions: BMI and ALC were positive correlated, but their effect on breast cancer prognosis was opposite. Patients with high BMI/low ALC had worse DFS than others. Underlying mechanisms for effect of BMI/ALC on breast cancer prognosis should be studied in the future.
Files in This Item:
T202103073.pdf Download
DOI
10.1038/s41416-021-01391-0
Appears in Collections:
6. Others (기타) > Gangnam Severance Hospital Health Promotion Center(강남세브란스병원 체크업) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Bae, Soong June(배숭준) ORCID logo https://orcid.org/0000-0002-0012-9694
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Ji, Junghwan(지정환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184491
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