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LI-RADS Major Features on MRI for Diagnosing Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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dc.contributor.author박미숙-
dc.contributor.author신재승-
dc.contributor.author윤자경-
dc.contributor.author이선영-
dc.contributor.author정용은-
dc.contributor.author최진영-
dc.contributor.author신재승-
dc.contributor.author윤자경-
dc.contributor.author이선영-
dc.contributor.author정용은-
dc.contributor.author최진영-
dc.date.accessioned2021-09-29T01:36:06Z-
dc.date.available2021-09-29T01:36:06Z-
dc.date.issued2021-08-
dc.identifier.issn1053-1807-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184451-
dc.description.abstractBackground: The reported diagnostic performance for hepatocellular carcinoma (HCC) of each major imaging feature on MRI using standardized definitions of the Liver Imaging Reporting and Data System (LI-RADS) is variable. It is important to know the actual performance of each LI-RADS major imaging feature for imaging diagnosis of HCC and determine the sources of heterogeneity between the reported results. Purpose: To systematically determine the performance of each major imaging feature of LI-RADS for diagnosing HCC using either extracellular contrast agent-enhanced MRI (ECA-MRI) or gadoxetate disodium-enhanced MRI (EOB-MRI). Study type: Systematic review and meta-analysis. Subjects: Sixteen original articles with 3542 lesions. Field strength: A 1.5 T and 3.0 T. Assessment: Data extraction was independently performed by two reviewers who identified and reviewed original articles reporting the diagnostic performance of each LI-RADS major imaging feature-arterial phase hyperenhancement (APHE), observation size, washout appearance, enhancing "capsule," and threshold growth-using MRI. Study characteristics, study population characteristics, MRI characteristics, contrast agent, LI-RADS version, reference standards, and study outcomes were extracted from included studies. Risk of bias and concerns regarding applicability were evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Statistical tests: Bivariate random-effects models were used to obtain summary estimates of the diagnostic performance of each LI-RADS major imaging feature. Hierarchical summary receiver operating characteristic curves were plotted. Meta-regression analyses were performed to explore potential sources of heterogeneity. Results: The pooled per-observation sensitivities and specificities for diagnosing HCC were 85% (95% confidence interval [CI] = 78%-89%) and 57% (95% CI = 44%-70%) for arterial phase hyperenhancement (APHE), 77% (95% CI = 72%-82%), and 74% (95% CI = 63%-83%) for washout appearance, and 52% (95% CI = 41%-64%) and 90% (95% CI = 85%-94%) for enhancing "capsule," respectively. Data conclusions: Among the LI-RADS major features, the sensitivity was the highest for APHE and the specificity was the highest for enhancing "capsule" in the diagnosis of HCC. Evidence level: 3 TECHNICAL EFFICACY: Stage 2.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJOURNAL OF MAGNETIC RESONANCE IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLI-RADS Major Features on MRI for Diagnosing Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorJaeseung Shin-
dc.contributor.googleauthorSunyoung Lee-
dc.contributor.googleauthorJa Kyung Yoon-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorMi-Suk Park-
dc.identifier.doi10.1002/jmri.27570-
dc.contributor.localIdA01463-
dc.contributor.localIdA05599-
dc.contributor.localIdA05487-
dc.contributor.localIdA05659-
dc.contributor.localIdA03662-
dc.contributor.localIdA04200-
dc.contributor.localIdA05599-
dc.contributor.localIdA05487-
dc.contributor.localIdA05659-
dc.contributor.localIdA03662-
dc.contributor.localIdA04200-
dc.relation.journalcodeJ01567-
dc.identifier.eissn1522-2586-
dc.identifier.pmid33638582-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/jmri.27570-
dc.subject.keywordcontrast media-
dc.subject.keyworddiagnosis-
dc.subject.keywordliver neoplasms-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keywordsensitivity and specificity-
dc.contributor.alternativeNamePark, Mi Sook-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor신재승-
dc.contributor.affiliatedAuthor윤자경-
dc.contributor.affiliatedAuthor이선영-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor신재승-
dc.contributor.affiliatedAuthor윤자경-
dc.contributor.affiliatedAuthor이선영-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor최진영-
dc.citation.volume54-
dc.citation.number2-
dc.citation.startPage518-
dc.citation.endPage525-
dc.identifier.bibliographicCitationJOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.54(2) : 518-525, 2021-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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