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Pre-Metabolic Syndrome and Incidence of Type 2 Diabetes and Hypertension: From the Korean Genome and Epidemiology Study

Authors
 A-Ra Cho  ;  Yu-Jin Kwon  ;  Jong-Koo Kim 
Citation
 JOURNAL OF PERSONALIZED MEDICINE, Vol.11(8) : 700, 2021-07 
Journal Title
JOURNAL OF PERSONALIZED MEDICINE
Issue Date
2021-07
Keywords
cohort study ; hypertension ; metabolic syndrome ; pre-metabolic syndrome ; type 2 diabetes mellitus
Abstract
The aim of this study was to investigate the prevalence of premetabolic syndrome (pre-MetSyn) and its components and to longitudinally examine their association with new-onset type 2 diabetes (T2D) or hypertension. A total of 4037 men and 4400 women aged 40 to 69 years were selected from the Korean Genome and Epidemiology Study, observed from 2001 to 2014. Pre-MetSyn was defined as the presence of one or two components of MetSyn (B, elevated blood pressure; G, elevated glucose; H, low HDL-cholesterol; T, elevated triglycerides; W, increased waist circumference). The prevalence of pre-MetSyn was higher than that of non-MetSyn and MetSyn in both men and women. In multivariate Cox regression analyses, G, T, G+T, W+G, B+G, B+T, W+T, B+H, and H+T in men and G, T, G+H, B+T, and H+T in women were significantly associated with new-onset T2D. B, W, B+H, B+T, W+H, and W+T in men and B, B+T, B+H, B+W, and W+H in women were significantly associated with new-onset hypertension. The prevalence of pre-MetSyn components and their associations with new-onset T2D or hypertension differed according to sex and disease. Our results suggest that specific phenotypes of pre-MetSyn may be important factors for predicting and preventing the development of T2D and hypertension.
Files in This Item:
T202103017.pdf Download
DOI
10.3390/jpm11080700
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Cho, A Ra(조아라) ORCID logo https://orcid.org/0000-0002-3645-2282
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184440
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