189 344

Cited 0 times in

Potential of an Enzyme Mixture of Glucose Oxidase, Glucosyl Transferase, and Fructosyl Transferase as an Antidiabetic Medicine

Authors
 Daham Kim  ;  Juyeon Yu  ;  Eun Kyung Wang  ;  Soohyun Lee  ;  Jung Seung Kim  ;  Jihwan Hwang  ;  Cheol Ryong Ku  ;  Yoon Hee Cho  ;  Eun Jig Lee 
Citation
 BIOMEDICINES, Vol.9(7) : 745, 2021-07 
Journal Title
BIOMEDICINES
Issue Date
2021-07
Keywords
antidiabetic effect ; fructosyl transferase ; glucose oxidase ; glucosyl transferase ; gut microbiota ; lipid profile
Abstract
An enzyme mixture (EM) of glucose oxidase, glucosyl transferase, and fructosyl transferase can regulate glucose absorption into the body by converting carbohydrates in food to indigestible oligosaccharides. We evaluated the antidiabetic effects of repeated oral administration of EM in db/db mice. Seven-week-old db/db mice were divided into control, voglibose, and EM groups. Drugs were administered orally mixed with limited feed for one month. Glucose levels were measured every week. A meal tolerance test was conducted after overnight fasting, before the mice were sacrificed. There were no differences in body weight or food intake between the groups. EM treatment reduced blood glucose levels compared with those in the control group. Blood glucose levels during the meal tolerance test were significantly lower in the EM group than those in the control group. A significant decrease in triglyceride level and a tendency for decreased low-density lipoprotein were observed in the EM group compared with in the control group. The Bacteroidetes-to-Firmicutes ratio was higher in the EM group than that in the control group. EM may be useful for people at risk of hyperglycemia or diabetes who need to safely regulate their blood glucose levels. EM may also improve lipid and gut microbiota profiles.
Files in This Item:
T202103001.pdf Download
DOI
10.3390/biomedicines9070745
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ku, Cheol Ryong(구철룡) ORCID logo https://orcid.org/0000-0001-8693-9630
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Cho, Yoon Hee(조윤희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184424
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links