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Dynamics of liver stiffness-based risk prediction model during antiviral therapy in patients with chronic hepatitis B

Authors
 Hye Yeon Chon  ;  Yeon Seok Seo  ;  Jung Il Lee  ;  Byung Seok Kim  ;  Byoung Kuk Jang  ;  Sang Gyune Kim  ;  Ki Tae Suk  ;  In Hee Kim  ;  Jin-Woo Lee  ;  Young Eun Chon  ;  Moon Young Kim  ;  Soung Won Jeong  ;  Han Ah Lee  ;  Sun Young Yim  ;  Soon Ho Um  ;  Hyun Woong Lee  ;  Kwan Sik Lee  ;  Jeong Eun Song  ;  Chang Hyeong Lee  ;  Woo Jin Chung  ;  Jae Seok Hwang  ;  Jeong-Ju Yoo  ;  Young Seok Kim  ;  Dong Joon Kim  ;  Chang Hun Lee  ;  Jung Hwan Yu  ;  Yeon Jung Ha  ;  Mi Na Kim  ;  Joo Ho Lee  ;  Seong Gyu Hwang  ;  Seong Hee Kang  ;  Soon Koo Baik  ;  Jae Young Jang  ;  Sang Jun Suh  ;  Young Kul Jung  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Hyung Joon Yim  ;  Seung Up Kim 
Citation
 EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol.33(6) : 885-893, 2021-06 
Journal Title
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
ISSN
 0954-691X 
Issue Date
2021-06
Abstract
Objective: The liver stiffness-based risk prediction models predict hepatocellular carcinoma (HCC) development. We investigated the influence of antiviral therapy (AVT) on liver stiffness-based risk prediction model in patients with chronic hepatitis B (CHB).

Methods: Patients with CHB who initiated AVT were retrospectively recruited from 13 referral Korean institutes. The modified risk estimation for hepatocellular carcinoma in chronic hepatitis B (mREACH-B) model was selected for the analysis.

Results: Between 2007 and 2015, 1034 patients with CHB were recruited. The mean age of the study population (639 men and 395 women) was 46.8 years. During AVT, the mREACH-B score significantly decreased from the baseline to 3 years of AVT (mean 9.21 → 7.46, P < 0.05) and was maintained until 5 years of AVT (mean 7.23, P > 0.05). The proportion of high-risk patients (mREACH-B score ≥11) was significantly reduced from the baseline to 2 years of AVT (36.4% → 16.4%, P < 0.001) and was maintained until 5 years of AVT (12.2%, P > 0.05). The mREACH-B scores at baseline and 1 year of AVT independently predicted HCC development (hazard ratio = 1.209-1.224) (all P < 0.05). The cumulative incidence rate of HCC was significantly different at 5 years of AVT among risk groups (high vs. high-intermediate vs. low-intermediate vs. low) from baseline (4.5% vs. 3.2% vs. 1.5% vs. 0.8%) and 1 year (11.8% vs. 4.6% vs. 1.8% vs. 0.6%) (all P < 0.05, log-rank tests).

Conclusions: The mREACH-B score was dynamically changed during AVT. Thus, repeated assessment of the mREACH-B score is required to predict the changing risk of HCC development in patients with CHB undergoing AVT.
Full Text
https://journals.lww.com/eurojgh/Fulltext/2021/06000/Dynamics_of_liver_stiffness_based_risk_prediction.15.aspx
DOI
10.1097/MEG.0000000000001794
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Jung Il(이정일) ORCID logo https://orcid.org/0000-0002-0142-1398
Lee, Hyun Woong(이현웅) ORCID logo https://orcid.org/0000-0002-6958-3035
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184376
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