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Dynamics of liver stiffness-based risk prediction model during antiviral therapy in patients with chronic hepatitis B

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dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author이정일-
dc.contributor.author이현웅-
dc.contributor.author한광협-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.contributor.author이정일-
dc.contributor.author이현웅-
dc.contributor.author한광협-
dc.date.accessioned2021-09-29T01:28:00Z-
dc.date.available2021-09-29T01:28:00Z-
dc.date.issued2021-06-
dc.identifier.issn0954-691X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184376-
dc.description.abstractObjective: The liver stiffness-based risk prediction models predict hepatocellular carcinoma (HCC) development. We investigated the influence of antiviral therapy (AVT) on liver stiffness-based risk prediction model in patients with chronic hepatitis B (CHB). Methods: Patients with CHB who initiated AVT were retrospectively recruited from 13 referral Korean institutes. The modified risk estimation for hepatocellular carcinoma in chronic hepatitis B (mREACH-B) model was selected for the analysis. Results: Between 2007 and 2015, 1034 patients with CHB were recruited. The mean age of the study population (639 men and 395 women) was 46.8 years. During AVT, the mREACH-B score significantly decreased from the baseline to 3 years of AVT (mean 9.21 → 7.46, P < 0.05) and was maintained until 5 years of AVT (mean 7.23, P > 0.05). The proportion of high-risk patients (mREACH-B score ≥11) was significantly reduced from the baseline to 2 years of AVT (36.4% → 16.4%, P < 0.001) and was maintained until 5 years of AVT (12.2%, P > 0.05). The mREACH-B scores at baseline and 1 year of AVT independently predicted HCC development (hazard ratio = 1.209-1.224) (all P < 0.05). The cumulative incidence rate of HCC was significantly different at 5 years of AVT among risk groups (high vs. high-intermediate vs. low-intermediate vs. low) from baseline (4.5% vs. 3.2% vs. 1.5% vs. 0.8%) and 1 year (11.8% vs. 4.6% vs. 1.8% vs. 0.6%) (all P < 0.05, log-rank tests). Conclusions: The mREACH-B score was dynamically changed during AVT. Thus, repeated assessment of the mREACH-B score is required to predict the changing risk of HCC development in patients with CHB undergoing AVT.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams And Wilkins-
dc.relation.isPartOfEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDynamics of liver stiffness-based risk prediction model during antiviral therapy in patients with chronic hepatitis B-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Yeon Chon-
dc.contributor.googleauthorYeon Seok Seo-
dc.contributor.googleauthorJung Il Lee-
dc.contributor.googleauthorByung Seok Kim-
dc.contributor.googleauthorByoung Kuk Jang-
dc.contributor.googleauthorSang Gyune Kim-
dc.contributor.googleauthorKi Tae Suk-
dc.contributor.googleauthorIn Hee Kim-
dc.contributor.googleauthorJin-Woo Lee-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorMoon Young Kim-
dc.contributor.googleauthorSoung Won Jeong-
dc.contributor.googleauthorHan Ah Lee-
dc.contributor.googleauthorSun Young Yim-
dc.contributor.googleauthorSoon Ho Um-
dc.contributor.googleauthorHyun Woong Lee-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorJeong Eun Song-
dc.contributor.googleauthorChang Hyeong Lee-
dc.contributor.googleauthorWoo Jin Chung-
dc.contributor.googleauthorJae Seok Hwang-
dc.contributor.googleauthorJeong-Ju Yoo-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorDong Joon Kim-
dc.contributor.googleauthorChang Hun Lee-
dc.contributor.googleauthorJung Hwan Yu-
dc.contributor.googleauthorYeon Jung Ha-
dc.contributor.googleauthorMi Na Kim-
dc.contributor.googleauthorJoo Ho Lee-
dc.contributor.googleauthorSeong Gyu Hwang-
dc.contributor.googleauthorSeong Hee Kang-
dc.contributor.googleauthorSoon Koo Baik-
dc.contributor.googleauthorJae Young Jang-
dc.contributor.googleauthorSang Jun Suh-
dc.contributor.googleauthorYoung Kul Jung-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorHyung Joon Yim-
dc.contributor.googleauthorSeung Up Kim-
dc.identifier.doi10.1097/MEG.0000000000001794-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03122-
dc.contributor.localIdA03292-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03122-
dc.contributor.localIdA03292-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ00821-
dc.identifier.eissn1473-5687-
dc.identifier.pmid32541238-
dc.identifier.urlhttps://journals.lww.com/eurojgh/Fulltext/2021/06000/Dynamics_of_liver_stiffness_based_risk_prediction.15.aspx-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이관식-
dc.contributor.affiliatedAuthor이정일-
dc.contributor.affiliatedAuthor이현웅-
dc.contributor.affiliatedAuthor한광협-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이관식-
dc.contributor.affiliatedAuthor이정일-
dc.contributor.affiliatedAuthor이현웅-
dc.contributor.affiliatedAuthor한광협-
dc.citation.volume33-
dc.citation.number6-
dc.citation.startPage885-
dc.citation.endPage893-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol.33(6) : 885-893, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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