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Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study

Authors
 Jaelim Cho  ;  Seongho Seo  ;  Woo-Ram Kim  ;  Changsoo Kim  ;  Young Noh 
Citation
 FRONTIERS IN AGING NEUROSCIENCE, Vol.13 : 694629, 2021-06 
Journal Title
FRONTIERS IN AGING NEUROSCIENCE
Issue Date
2021-06
Keywords
MRI ; abdominal fat ; cortical thickness ; neuroimaging ; visceral fat
Abstract
Background: Despite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly.

Purpose: We aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population.

Methods: This cross-sectional study included elderly individuals without dementia (n = 316). Areas of visceral fat and subcutaneous fat (cm2) were estimated from computed tomography scans. Regional cortical thicknesses (mm) were obtained by analyzing brain magnetic resonance images. Given the inverted U-shaped relationship between visceral fat area and global cortical thickness (examined using a generalized additive model), visceral fat area was categorized into quintiles, with the middle quintile being the reference group. A generalized linear model was built to explore brain regions associated with visceral fat. The same approach was used for subcutaneous fat.

Results: The mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = -0.04 mm, standard error (SE) = 0.02 mm, p = 0.004], parietal (β = -0.04 mm, SE = 0.02 mm, p = 0.01), temporal (β = -0.05 mm, SE = 0.02 mm, p = 0.002), cingulate (β = -0.06 mm, SE = 0.02 mm, p = 0.01), and insula lobes (β = -0.06 mm, SE = 0.03 mm, p = 0.02). None of the regional cortical thicknesses significantly differed between the highest and the middle quintile groups of subcutaneous fat area.

Conclusion: The findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.
Files in This Item:
T202102934.pdf Download
DOI
10.3389/fnagi.2021.694629
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184373
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