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Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study

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dc.contributor.author김창수-
dc.contributor.author조재림-
dc.date.accessioned2021-09-29T01:27:41Z-
dc.date.available2021-09-29T01:27:41Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184373-
dc.description.abstractBackground: Despite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly. Purpose: We aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population. Methods: This cross-sectional study included elderly individuals without dementia (n = 316). Areas of visceral fat and subcutaneous fat (cm2) were estimated from computed tomography scans. Regional cortical thicknesses (mm) were obtained by analyzing brain magnetic resonance images. Given the inverted U-shaped relationship between visceral fat area and global cortical thickness (examined using a generalized additive model), visceral fat area was categorized into quintiles, with the middle quintile being the reference group. A generalized linear model was built to explore brain regions associated with visceral fat. The same approach was used for subcutaneous fat. Results: The mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = -0.04 mm, standard error (SE) = 0.02 mm, p = 0.004], parietal (β = -0.04 mm, SE = 0.02 mm, p = 0.01), temporal (β = -0.05 mm, SE = 0.02 mm, p = 0.002), cingulate (β = -0.06 mm, SE = 0.02 mm, p = 0.01), and insula lobes (β = -0.06 mm, SE = 0.03 mm, p = 0.02). None of the regional cortical thicknesses significantly differed between the highest and the middle quintile groups of subcutaneous fat area. Conclusion: The findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN AGING NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorJaelim Cho-
dc.contributor.googleauthorSeongho Seo-
dc.contributor.googleauthorWoo-Ram Kim-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorYoung Noh-
dc.identifier.doi10.3389/fnagi.2021.694629-
dc.contributor.localIdA01042-
dc.relation.journalcodeJ00908-
dc.identifier.eissn1663-4365-
dc.identifier.pmid34248609-
dc.subject.keywordMRI-
dc.subject.keywordabdominal fat-
dc.subject.keywordcortical thickness-
dc.subject.keywordneuroimaging-
dc.subject.keywordvisceral fat-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.affiliatedAuthor김창수-
dc.citation.volume13-
dc.citation.startPage694629-
dc.identifier.bibliographicCitationFRONTIERS IN AGING NEUROSCIENCE, Vol.13 : 694629, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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