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Increase of Vδ2 + T Cells That Robustly Produce IL-17A in Advanced Abdominal Aortic Aneurysm Tissues

Authors
 In-Ho Seo  ;  Seung-Jun Lee  ;  Tae Wook Noh  ;  Jung-Hwan Kim  ;  Hyun-Chel Joo  ;  Eui-Cheol Shin  ;  Su-Hyung Park  ;  Young-Guk Ko 
Citation
 IMMUNE NETWORK, Vol.21(2) : e17, 2021-04 
Journal Title
IMMUNE NETWORK
ISSN
 1598-2629 
Issue Date
2021-04
Keywords
Abdominal aortic aneurysm ; Gamma Delta T cells ; IL-17A
Abstract
Abdominal aortic aneurysm (AAA) is a chronic dilation of the aorta with a tendency to enlarge and eventually rupture, which constitutes a major cause of cardiovascular mortality. Although T-cell infiltrates have been observed in AAA, the cellular, phenotypic, and functional characteristics of these tissue-infiltrating T cells are not fully understood. Here, we investigated the proportional changes of T-cell subsets-including CD4+ T cells, CD8+ T cells, and γδ T cells-and their effector functions in AAAs. We found that Vδ2+ T cells were presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue and PBMCs from patients with AAA. In contrast, no differences were observed in the frequencies of CD4+, CD8+, and Vδ1+ T cells. Moreover, we observed that the Vδ2+ T cells from AAA tissue displayed immunophenotypes indicative of CCR5+ non-exhausted effector memory cells, with a decreased proportion of CD16+ cells. Finally, we found that these Vδ2+ T cells were the main source of IL-17A in abdominal aortic aneurysmal tissue. In conclusion, our results suggest that increased Vδ2+ T cells that robustly produce IL-17A in aortic aneurysmal tissue may contribute to AAA pathogenesis and progression.
Files in This Item:
T202102929.pdf Download
DOI
10.4110/in.2021.21.e17
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Lee, Seung-Jun(이승준) ORCID logo https://orcid.org/0000-0002-9201-4818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184368
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