Cited 7 times in
Increase of Vδ2 + T Cells That Robustly Produce IL-17A in Advanced Abdominal Aortic Aneurysm Tissues
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 이승준 | - |
dc.date.accessioned | 2021-09-29T01:27:08Z | - |
dc.date.available | 2021-09-29T01:27:08Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184368 | - |
dc.description.abstract | Abdominal aortic aneurysm (AAA) is a chronic dilation of the aorta with a tendency to enlarge and eventually rupture, which constitutes a major cause of cardiovascular mortality. Although T-cell infiltrates have been observed in AAA, the cellular, phenotypic, and functional characteristics of these tissue-infiltrating T cells are not fully understood. Here, we investigated the proportional changes of T-cell subsets-including CD4+ T cells, CD8+ T cells, and γδ T cells-and their effector functions in AAAs. We found that Vδ2+ T cells were presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue and PBMCs from patients with AAA. In contrast, no differences were observed in the frequencies of CD4+, CD8+, and Vδ1+ T cells. Moreover, we observed that the Vδ2+ T cells from AAA tissue displayed immunophenotypes indicative of CCR5+ non-exhausted effector memory cells, with a decreased proportion of CD16+ cells. Finally, we found that these Vδ2+ T cells were the main source of IL-17A in abdominal aortic aneurysmal tissue. In conclusion, our results suggest that increased Vδ2+ T cells that robustly produce IL-17A in aortic aneurysmal tissue may contribute to AAA pathogenesis and progression. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increase of Vδ2 + T Cells That Robustly Produce IL-17A in Advanced Abdominal Aortic Aneurysm Tissues | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | In-Ho Seo | - |
dc.contributor.googleauthor | Seung-Jun Lee | - |
dc.contributor.googleauthor | Tae Wook Noh | - |
dc.contributor.googleauthor | Jung-Hwan Kim | - |
dc.contributor.googleauthor | Hyun-Chel Joo | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.identifier.doi | 10.4110/in.2021.21.e17 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A02927 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.identifier.pmid | 33996173 | - |
dc.subject.keyword | Abdominal aortic aneurysm | - |
dc.subject.keyword | Gamma Delta T cells | - |
dc.subject.keyword | IL-17A | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.contributor.affiliatedAuthor | 이승준 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e17 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.21(2) : e17, 2021-04 | - |
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