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Optical Coherent Tomography Predicts Long-Term Visual Outcome of Pituitary Adenoma Surgery: New Perspectives From a 5-Year Follow-up Study

Authors
 Young Soo Chung  ;  Minkyun Na  ;  Jihwan Yoo  ;  Woohyun Kim  ;  In-Ho Jung  ;  Ju Hyung Moon  ;  Junwon Lee  ;  Sun Ho Kim  ;  Eui Hyun Kim 
Citation
 NEUROSURGERY, Vol.88(1) : 106-112, 2021-01 
Journal Title
NEUROSURGERY
ISSN
 0148-396X 
Issue Date
2021-01
MeSH
Adenoma / complications* ; Adenoma / surgery ; Adult ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nerve Compression Syndromes / etiology* ; Nerve Compression Syndromes / pathology ; Neurosurgical Procedures ; Pituitary Neoplasms / complications* ; Pituitary Neoplasms / surgery ; Postoperative Period ; Recovery of Function* / physiology ; Retina / diagnostic imaging ; Retina / pathology ; Retinal Neurons / pathology* ; Retrospective Studies ; Tomography, Optical Coherence / methods ; Vision Disorders / etiology ; Vision Disorders / pathology
Keywords
Optical coherence tomography ; Pituitary adenoma ; Retinal nerve fiber thickness ; Transsphenoidal approach ; Visual recovery
Abstract
Background: Compressive optic neuropathy is the most common indication for transsphenoidal surgery for pituitary adenomas. Optical coherence tomography (OCT) is a useful visual assessment tool for predicting postoperative visual field recovery.

Objective: To analyze visual parameters and their association based on long-term follow-up.

Methods: Only pituitary adenoma patients with abnormal visual field defects were selected. A total of 188 eyes from 113 patients assessed by visual field index (VFI) and 262 eyes from 155 patients assessed by mean deviation (MD) were enrolled in this study. Postoperative VFI, MD, and retinal nerve fiber layer (RNFL) thickness were evaluated and followed up. After classifying the patients into normal (>5%) and thin (<5%) RNFL groups, we investigated whether preoperative RNFL could predict visual field outcomes. We also observed how RNFL changes after surgery on a long-term basis.

Results: Both preoperative VFI and MD had a linear proportional relationship with preoperative RNFL thickness. Sustained improvement of the visual field was observed after surgery in both groups, and the degree of improvement over time in each group was similar. RNFL thickness continued to decrease until 36 mo after surgery (80.2 ± 13.3 μm to 66.6 ± 11.9 μm) while visual field continued to improve (VFI, 61.8 ± 24.5 to 84.3 ± 15.4; MD, -12.9 ± 7.3 dB to -6.3 ± 5.9 dB).

Conclusion: Patients with thin preoperative RNFL may experience visual recovery similar to those with normal preoperative RNFL; however, the probability of normalized visual fields was not comparable. RNFL thickness showed a strong correlation with preoperative visual field defect. Long-term follow-up observation revealed a discrepancy between anatomic and functional recovery.
Full Text
https://academic.oup.com/neurosurgery/article/88/1/106/5879452
DOI
10.1093/neuros/nyaa318
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sun Ho(김선호) ORCID logo https://orcid.org/0000-0003-0970-3848
Kim, Woohyun(김우현) ORCID logo https://orcid.org/0000-0002-2936-3740
Kim, Eui Hyun(김의현) ORCID logo https://orcid.org/0000-0002-2523-7122
Moon, Ju Hyung(문주형)
Yoo, Jihwan(유지환)
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
Jung, In-Ho(정인호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184321
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