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The role of gonadotropin-releasing hormone agonists in female fertility preservation

Authors
 Jae Hoon Lee  ;  Young Sik Choi 
Citation
 Clinical and Experimental Reproductive Medicine, Vol.48(1) : 11-26, 2021-02 
Journal Title
Clinical and Experimental Reproductive Medicine
ISSN
 2233-8233 
Issue Date
2021-02
Keywords
Chemotherapy ; Fertility preservation ; Gonadotropin-releasing hormone agonist ; Premature ovarian insufficiency
Abstract
Advances in anticancer treatments have resulted in increasing survival rates among cancer patients. Accordingly, the quality of life after treatment, particularly the preservation of fertility, has gradually emerged as an essential consideration. Cryopreservation of embryos or unfertilized oocytes has been considered as the standard method of fertility preservation among young women facing gonadotoxic chemotherapy. Other methods, including ovarian suppression and ovarian tissue cryopreservation, have been considered experimental. Recent large-scale randomized controlled trials have demonstrated that temporary ovarian suppression using gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy is beneficial for preventing chemotherapy-induced premature ovarian insufficiency in breast cancer patients. It should also be emphasized that GnRHa use during chemotherapy does not replace established fertility preservation methods. All young women facing gonadotoxic chemotherapy should be counseled about and offered various options for fertility preservation, including both GnRHa use and cryopreservation of embryos, oocytes, and/or ovarian tissue.
Files in This Item:
T202102789.pdf Download
DOI
10.5653/cerm.2020.04049
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0003-4223-1395
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184303
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