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Age-group-specific reference intervals for anti-Müllerian hormone and its diagnostic performance for polycystic ovary syndrome in a Korean population

Authors
 Junhyup Song  ;  Yongjung Park  ;  Hae Weon Cho  ;  Sang-Guk Lee  ;  Sinyoung Kim  ;  Jong Baeck Lim 
Citation
 JOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.35(7) : e23861, 2021-07 
Journal Title
JOURNAL OF CLINICAL LABORATORY ANALYSIS
ISSN
 0887-8013 
Issue Date
2021-07
Keywords
age-group-specific ; anti-Müllerian hormone ; diagnostic performance ; polycystic ovary syndrome ; reference interval
Abstract
Background: We established age-group-specific reference intervals for serum anti-Müllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.

Methods: We analyzed serum levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS. Age-group-specific reference intervals and AMH diagnostic performance were estimated.

Results: The PCOS group had a median AMH level of 7.0 µg/L, which was higher than for the healthy (1.8 µg/L) and the benign gynecologic diseases (2.7 µg/L) groups. The upper 97.5% reference limits for age groups 12-20 years, 21-34 years, and 35-46 years were 13.2 µg/L, 15.8 µg/L, and 6.6 µg/L, respectively. The area under the curve (AUC) values to estimate AMH ability to discriminate PCOS from healthy women for each age group were 0.741, 0.785, and 0.789, respectively. AUCs for LH/FSH were 0.719, 0.672, and 0.590.

Conclusions: The better diagnostic ability of AMH over LH/FSH in women of late childbearing ages indicates that age and other clinical characteristics should be considered when interpreting these test results.
Files in This Item:
T202102708.pdf Download
DOI
10.1002/jcla.23861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Park, Yong Jung(박용정) ORCID logo https://orcid.org/0000-0001-5668-4120
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184270
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