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한국인 췌장암 환자에서 발견한 UGT1A1*37 대립유전자 1예 보고

Other Titles
 Identification of a UGT1A1*37 Allele in a Korean Patient with Pancreatic Cancer 
 김홍경  ;  김보연  ;  김윤정  ;  이경아 
 Laboratory Medicine Online, Vol.11(3) : 199-202, 2021-07 
Journal Title
Laboratory Medicine Online
Issue Date
UGT1A1 genotyping ; UGT1A1*37 ; Irinotecan toxicity ; Neutropenia
UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that catalyzes glucuronidation of substances, including bilirubin and other drug metabo lites. Certain UGT1A1 polymorphisms reduce UGT1A1 activity, notably UGT1A1*28 contains thymine-adenine repeats in the TATA box of the promo tor region. Irinotecan, a chemotherapy agent for solid cancers, is converted in the body to an active metabolite, SN-28, and then excreted, after
being conjugated with glucuronide by UGT1A1. If UGT1A1 activity decreases (e.g. UGT1A1*28), the risk of irinotecan toxicity increases, which can
develop into severe neutropenia and diarrhea. UGT1A1*37, a rare allele that has never been found in Asians, was previously reported to be asso ciated with severe neutropenia by reducing UGT1A1 activity further than UGT1A1*28. In this study, we first detected UGT1A1*37 in a 69-year-old
Korean woman diagnosed with pancreatic cancer and excluded irinotecan from her chemotherapy regimen, in consideration of the increased risk
of toxicity, based on pre-treatment UGT1A1 genotyping.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Boyeon(김보연)
Kim, Yoon Jung(김윤정) ORCID logo https://orcid.org/0000-0002-4370-4265
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
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