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한국인 췌장암 환자에서 발견한 UGT1A1*37 대립유전자 1예 보고
DC Field | Value | Language |
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dc.contributor.author | 김보연 | - |
dc.contributor.author | 김윤정 | - |
dc.contributor.author | 이경아 | - |
dc.contributor.author | 김홍경 | - |
dc.date.accessioned | 2021-09-29T01:12:56Z | - |
dc.date.available | 2021-09-29T01:12:56Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184250 | - |
dc.description.abstract | UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme that catalyzes glucuronidation of substances, including bilirubin and other drug metabo lites. Certain UGT1A1 polymorphisms reduce UGT1A1 activity, notably UGT1A1*28 contains thymine-adenine repeats in the TATA box of the promo tor region. Irinotecan, a chemotherapy agent for solid cancers, is converted in the body to an active metabolite, SN-28, and then excreted, after being conjugated with glucuronide by UGT1A1. If UGT1A1 activity decreases (e.g. UGT1A1*28), the risk of irinotecan toxicity increases, which can develop into severe neutropenia and diarrhea. UGT1A1*37, a rare allele that has never been found in Asians, was previously reported to be asso ciated with severe neutropenia by reducing UGT1A1 activity further than UGT1A1*28. In this study, we first detected UGT1A1*37 in a 69-year-old Korean woman diagnosed with pancreatic cancer and excluded irinotecan from her chemotherapy regimen, in consideration of the increased risk of toxicity, based on pre-treatment UGT1A1 genotyping. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | Korean Society for Laboratory Medicine | - |
dc.relation.isPartOf | Laboratory Medicine Online | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 한국인 췌장암 환자에서 발견한 UGT1A1*37 대립유전자 1예 보고 | - |
dc.title.alternative | Identification of a UGT1A1*37 Allele in a Korean Patient with Pancreatic Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 김홍경 | - |
dc.contributor.googleauthor | 김보연 | - |
dc.contributor.googleauthor | 김윤정 | - |
dc.contributor.googleauthor | 이경아 | - |
dc.identifier.doi | 10.47429/lmo.2021.11.3.199 | - |
dc.contributor.localId | A06055 | - |
dc.contributor.localId | A00793 | - |
dc.contributor.localId | A02647 | - |
dc.relation.journalcode | J02151 | - |
dc.identifier.eissn | 2093-6338 | - |
dc.subject.keyword | UGT1A1 genotyping | - |
dc.subject.keyword | UGT1A1*37 | - |
dc.subject.keyword | Irinotecan toxicity | - |
dc.subject.keyword | Neutropenia | - |
dc.contributor.alternativeName | Kim, Boyeon | - |
dc.contributor.affiliatedAuthor | 김보연 | - |
dc.contributor.affiliatedAuthor | 김윤정 | - |
dc.contributor.affiliatedAuthor | 이경아 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 202 | - |
dc.identifier.bibliographicCitation | Laboratory Medicine Online, Vol.11(3) : 199-202, 2021-07 | - |
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