Cited 0 times in
Regional Amyloid Burden Differences Evaluated Using Quantitative Cardiac MRI in Patients with Cardiac Amyloidosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영진 | - |
dc.contributor.author | 이혜정 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 허진 | - |
dc.contributor.author | 홍유진 | - |
dc.contributor.author | 한경화 | - |
dc.date.accessioned | 2021-09-29T01:11:02Z | - |
dc.date.available | 2021-09-29T01:11:02Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184237 | - |
dc.description.abstract | Objective: This study aimed to investigate the regional amyloid burden and myocardial deformation using T1 mapping and strain values in patients with cardiac amyloidosis (CA) according to late gadolinium enhancement (LGE) patterns. Materials and methods: Forty patients with CA were divided into 2 groups per LGE pattern, and 15 healthy subjects were enrolled. Global and regional native T1 and T2 mapping, extracellular volume (ECV), and cardiac magnetic resonance (CMR)-feature tracking strain values were compared in an intergroup and interregional manner. Results: Of the patients with CA, 32 had diffuse global LGE (group 2), and 8 had focal patchy or no LGE (group 1). Global native T1, T2, and ECV were significantly higher in groups 1 and 2 than in the control group (native T1: 1384.4 ms vs. 1466.8 ms vs. 1230.5 ms; T2: 53.8 ms vs. 54.2 ms vs. 48.9 ms; and ECV: 36.9% vs. 51.4% vs. 26.0%, respectively; all, p < 0.001). Basal ECV (53.7%) was significantly higher than the mid and apical ECVs (50.1% and 50.0%, respectively; p < 0.001) in group 2. Basal and mid peak radial strains (PRSs) and peak circumferential strains (PCSs) were significantly lower than the apical PRS and PCS, respectively (PRS, 15.6% vs. 16.7% vs. 26.9%; and PCS, -9.7% vs. -10.9% vs. -15.0%; all, p < 0.001). Basal ECV and basal strain (2-dimensional PRS) in group 2 showed a significant negative correlation (r = -0.623, p < 0.001). Group 1 showed no regional ECV differences (basal, 37.0%; mid, 35.9%; and apical, 38.3%; p = 0.184). Conclusion: Quantitative T1 mapping parameters such as native T1 and ECV may help diagnose early CA. ECV, in particular, can reflect regional differences in the amyloid deposition in patients with advanced CA, and increased basal ECV is related to decreased basal strain. Therefore, quantitative CMR parameters may help diagnose CA and determine its severity in patients with or without LGE. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Society of Radiology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Regional Amyloid Burden Differences Evaluated Using Quantitative Cardiac MRI in Patients with Cardiac Amyloidosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jin Young Kim | - |
dc.contributor.googleauthor | Yoo Jin Hong | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Hye Jeong Lee | - |
dc.contributor.googleauthor | Jin Hur | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.identifier.doi | 10.3348/kjr.2020.0579 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A03320 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04370 | - |
dc.contributor.localId | A04422 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 33686816 | - |
dc.subject.keyword | Extracellular space | - |
dc.subject.keyword | Feature tracking | - |
dc.subject.keyword | Heart | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Mapping | - |
dc.subject.keyword | Myocardium | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | 김영진 | - |
dc.contributor.affiliatedAuthor | 이혜정 | - |
dc.contributor.affiliatedAuthor | 최병욱 | - |
dc.contributor.affiliatedAuthor | 허진 | - |
dc.contributor.affiliatedAuthor | 홍유진 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 880 | - |
dc.citation.endPage | 889 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.22(6) : 880-889, 2021-06 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.