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Possible Therapeutic Options for Complex Regional Pain Syndrome

Authors
 Myeounghoon Cha  ;  Kyung Hee Lee  ;  Minjee Kwon  ;  Bae Hwan Lee 
Citation
 BIOMEDICINES, Vol.9(6) : 596, 2021-05 
Journal Title
BIOMEDICINES
Issue Date
2021-05
Keywords
URB597 ; chronic post-ischemic pain ; complex regional pain syndrome ; hydralazine ; pyrrolidine dithiocarbamate
Abstract
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma. Research on the pharmacological treatment of CRPS, however, has not been well investigated. In this study, we compared the pain relief effects of different drugs (URB597, pyrrolidine dithiocarbamate, and hydralazine) in a rat model of chronic post-ischemic pain-induced CRPS. After drug injection, CRPS-induced mechanical allodynia was significantly recovered. After three repetitive drug injections, mechanical sensitivity generally improved as hyper-nociception subsided. Reduced Nav1.7 expression at dorsal root ganglions (DRGs) was observed in the drug treatment groups. Neural imaging analysis revealed decreased neural activity for each drug treatment, compared to vehicle. In addition, treatments significantly reduced IL-1β, IL-6, and TNFα expression in DRGs. These results indicated that drugs could reduce the expression of inflammatory factors and alleviate the symptoms of chronic post-ischemic pain-induced CRPS.
Files in This Item:
T202102637.pdf Download
DOI
10.3390/biomedicines9060596
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184219
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