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Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

Authors
 Chan Keum Park  ;  Kwanghyun Lee  ;  Eun Woo Kim  ;  Sangah Kim  ;  Sang Yeop Lee  ;  Chan Yun Kim  ;  Gong Je Seong  ;  Hyoung Won Bae 
Citation
 EYE, Vol.35(7) : 1967-1976, 2021-07 
Journal Title
EYE
ISSN
 0950-222X 
Issue Date
2021-07
MeSH
Aged ; Angiography ; Blood Pressure ; Cross-Sectional Studies ; Glaucoma* / diagnostic imaging ; Humans ; Intraocular Pressure ; Nerve Fibers ; Retinal Ganglion Cells ; Retrospective Studies ; Tomography, Optical Coherence*
Abstract
Background: The association between retinal microvascular structure and glaucoma has been revealed in multiple studies using optical tomography angiography (OCTA), but limited information on the macular vessel density (mVD) in patients with glaucoma is available. In this study, we tried to identity the factors that affected macular VD (mVD) in glaucomatous eyes.

Methods: This retrospective cross-sectional study evaluated OCT and OCTA images from 92 eyes from 58 healthy subjects and 179 eyes from 103 glaucoma patients using the SD-OCT database from July 2017 to July 2018. Glaucomatous eyes were further divided into two groups according to history of disc haemorrhage (DH). Association between mVD and demographic characteristics, ganglion cell-inner plexiform layer (GCIPL) thickness, visual field mean deviation (MD) and systemic blood pressure was analysed in each group.

Results: In both healthy and glaucomatous eyes, mVD was inversely associated with age (β = -0.035, P = 0.025; β = -0.039, P = 0.018). In the glaucomatous eyes, mVD was significantly decreased, as the MD value was worse (β = 0.109, P = 0.002). In glaucomatous eyes with DH, mVD decreased as blood pressure increased (β = -0.111, P = 0.003) CONCLUSIONS: Reduced mVD is more common in older individuals in both healthy and glaucomatous eyes, and correlates with functional deterioration than structural damage in glaucomatous eyes. In glaucomatous eyes with DH, high systemic BP is associated with a reduction in mVD. This may indicate that glaucoma patients with DH are more susceptible to vascular damage secondary to hypertension.
Full Text
https://www.nature.com/articles/s41433-020-01199-x
DOI
10.1038/s41433-020-01199-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Kwanghyun(이광현) ORCID logo https://orcid.org/0000-0002-1587-3387
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184207
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