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Synthetic magnetic resonance imaging for quantitative parameter evaluation of temporomandibular joint disorders

 Chena Lee  ;  Yoon Joo Choi  ;  Kug Jin Jeon  ;  Sang-Sun Han 
 DENTOMAXILLOFACIAL RADIOLOGY, Vol.50(5) : 20200584, 2021-07 
Journal Title
Issue Date
Cone-Beam Computed Tomography ; Humans ; Joint Dislocations* / diagnostic imaging ; Magnetic Resonance Imaging ; Mandibular Condyle ; Temporomandibular Joint ; Temporomandibular Joint Disc / diagnostic imaging ; Temporomandibular Joint Disorders* / diagnostic imaging
imaging biomarker ; longitudinal relaxation time ; proton density value ; synthetic magnetic resonance imaging ; temporomandibular joint disorder
Objective: This study investigated the usefulness of quantitative parameters [longitudinal relaxation (T1), transverse relaxation (T2), and proton density (PD)] obtained with synthetic magnetic resonance imaging (MRI) in assessing the progression of temporomandibular joint (TMJ) disorders. Methods: For individual TMJ disorder diagnoses, the presence of disc displacement in MRI and the osseous change in cone-beam CT were investigated. Joints were classified into three stages: (1) silent stage, no disc displacement or osseous change; (2) incipient stage, presence of disc displacement and absence of osseous change; and (3) progressed stage, both disc displacement and osseous change. In synthetic MRI, the T1, T2, and PD values of the condyle bone marrow were measured simultaneously. The median T1, T2, and PD values were analyzed according to disc displacement, osseous changes, and joint stage. Results: Significant differences were observed in the T1 and PD values of joints with disc displacement or condylar osseous change compared to normal joints. The T1 and PD values also differed between the silent and progressed stages. The PD value differed between the silent and incipient groups, while the T2 value did not differ significantly among the three groups. Conclusion: The PD and T1 values of condylar bone marrow obtained from synthetic MRI can be used as sensitive indicators of TMJ disorder progression. The PD value of the bone marrow showed potential as a useful biomarker for recognizing the initial stages of TMJ disorders. Synthetic MRI is useful for the simultaneous acquisition of effective MRI parameters for evaluating TMJ disorders.
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2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Radiology (영상치의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Chena(이채나) ORCID logo https://orcid.org/0000-0002-8943-4192
Jeon, Kug Jin(전국진) ORCID logo https://orcid.org/0000-0002-5862-2975
Choi, Yoon Joo(최윤주) ORCID logo https://orcid.org/0000-0001-9225-3889
Han, Sang Sun(한상선) ORCID logo https://orcid.org/0000-0003-1775-7862
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