Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

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Authors: Jae-Won Hyun ; Hye Lim Lee ; Woo Kyo Jeong ; Hye Jung Lee ; Jong Hwa Shin ; Ju-Hong Min ; Byoung Joon Kim ; Seung Woo Kim ; Ha Young Shin ; Jeeyoung Oh ; Woojun Kim ; Hyun-June Shin ; Sun-Young Oh ; Hyunjin Kim ; Young-Min Lim ; So-Young Huh ; Eun Bin Cho ; Tai-Seung Nam ; Seung-Han Lee ; Sun-Young Kim ; Sa-Yoon Kang ; Suk Geun Han ; Eun Hee Sohn ; Seol-Hee Baek ; Byung-Jo Kim ; Sang-Soo Lee ; Jin Myoung Seok ; Yoon-Ho Hong ; Seong-Il Oh ; Jong Kuk Kim ; Kyong Jin Shin ; Ohyun Kwon ; Joong-Yang Cho ; Jong Seok Bae ; So Yeon Kim ; Yeseul Kim ; Min Young Lee ; Su-Hyun Kim ; Ho Jin Kim

Keywords: Aquaporin-4 ; adult ; myelin oligodendrocyte glycoprotein ; prevalence

Abstract: We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell-based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Seung Woo(김승우) https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) https://orcid.org/0000-0002-4408-8265

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