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Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

Authors
 Jae-Won Hyun  ;  Hye Lim Lee  ;  Woo Kyo Jeong  ;  Hye Jung Lee  ;  Jong Hwa Shin  ;  Ju-Hong Min  ;  Byoung Joon Kim  ;  Seung Woo Kim  ;  Ha Young Shin  ;  Jeeyoung Oh  ;  Woojun Kim  ;  Hyun-June Shin  ;  Sun-Young Oh  ;  Hyunjin Kim  ;  Young-Min Lim  ;  So-Young Huh  ;  Eun Bin Cho  ;  Tai-Seung Nam  ;  Seung-Han Lee  ;  Sun-Young Kim  ;  Sa-Yoon Kang  ;  Suk Geun Han  ;  Eun Hee Sohn  ;  Seol-Hee Baek  ;  Byung-Jo Kim  ;  Sang-Soo Lee  ;  Jin Myoung Seok  ;  Yoon-Ho Hong  ;  Seong-Il Oh  ;  Jong Kuk Kim  ;  Kyong Jin Shin  ;  Ohyun Kwon  ;  Joong-Yang Cho  ;  Jong Seok Bae  ;  So Yeon Kim  ;  Yeseul Kim  ;  Min Young Lee  ;  Su-Hyun Kim  ;  Ho Jin Kim 
Citation
 MULTIPLE SCLEROSIS, Vol.27(6) : 964-967, 2021-05 
Journal Title
MULTIPLE SCLEROSIS
ISSN
 1352-4585 
Issue Date
2021-05
Keywords
Aquaporin-4 ; adult ; myelin oligodendrocyte glycoprotein ; prevalence
Abstract
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell-based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
Full Text
https://journals.sagepub.com/doi/10.1177/1352458520948213
DOI
10.1177/1352458520948213
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184170
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