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Recurrence of clinical events at the same anatomical location in patients with MOG antibody-associated disease

Authors
 Jae-Won Hyun  ;  Young Nam Kwon  ;  Hye Lim Lee  ;  Woo Kyo Jeong  ;  Hye Jung Lee  ;  Byoung Joon Kim  ;  Seung Woo Kim  ;  Ha Young Shin  ;  Hyun-June Shin  ;  Sun-Young Oh  ;  Min Young Lee  ;  Su-Hyun Kim  ;  So-Young Huh  ;  Woojun Kim  ;  Min Su Park  ;  Sun-Young Kim  ;  Sung-Min Kim  ;  Ho Jin Kim 
Citation
 MULTIPLE SCLEROSIS, Vol.27(3) : 449-452, 2021-03 
Journal Title
MULTIPLE SCLEROSIS
ISSN
 1352-4585 
Issue Date
2021-03
Keywords
Myelin oligodendrocyte glycoprotein ; diagnosis ; dissemination ; location ; onset
Abstract
Objectives: Likelihood of clinical events occurring within the same anatomical location in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) was retrospectively investigated.

Methods: A total of 236 clinical events in 90 patients with MOGAD from nine referral hospitals were analyzed via logistic regression, and odds ratios (ORs) were calculated. Anatomical lesion location was divided into four groups; optic nerve, spinal cord, cerebral hemisphere, and brainstem/cerebellum.

Results: At all locations, there was an increased likelihood of a second attack occurring at the same location as the initial event (cerebral hemisphere OR = 22.14, brainstem/cerebellum OR = 18.4, spinal cord OR = 9.1, and optic nerve OR = 7.8). There was an increased likelihood of a third attack occurring at the same location as the initial event in the optic nerve (OR = 14.9), cerebral hemisphere (OR = 11.7), and spinal cord (OR = 6.7). There were positive trends toward a third clinical event occurring at the same location as the first and/or second events if the event was in the optic nerve (OR = 13.5), cerebral hemisphere (OR = 6.9), or spinal cord (OR = 5.7).

Conclusions: The current study suggests that clinical relapses of MOGAD during early stage tend to recur at the same anatomical locations in the central nervous system.
Full Text
https://journals.sagepub.com/doi/10.1177/1352458520913970
DOI
10.1177/1352458520913970
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184169
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