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Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches

Authors
 Felipe Rodolfo Pereira da Silva  ;  Larissa Dos Santos Pessoa  ;  Jae Il Shin  ;  Even Herlany Pereira Alves  ;  Reyce Santos Koga  ;  Camila Valente Smith  ;  Daniel Fernando Pereira Vasconcelos  ;  Anna Carolina Toledo da Cunha Pereira 
Citation
 CYTOKINE, Vol.138 : 155361, 2021-02 
Journal Title
CYTOKINE
ISSN
 1043-4666 
Issue Date
2021-02
Keywords
Alleles ; Genetic variations ; Odds ratio ; Periodontal diseases ; Risk factors
Abstract
Periodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility.
Full Text
https://www.sciencedirect.com/science/article/pii/S104346662030377
DOI
10.1016/j.cyto.2020.155361
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184165
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