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Polymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches

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dc.contributor.author신재일-
dc.date.accessioned2021-09-29T01:03:16Z-
dc.date.available2021-09-29T01:03:16Z-
dc.date.issued2021-02-
dc.identifier.issn1043-4666-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184165-
dc.description.abstractPeriodontitis is a high prevalent disease into the clinical dentistry. Genetic variations in interleukins (IL) genes were associated with chronic periodontitis (CP) and were focus of several meta-analyses. This study aimed to assess the noteworthiness in the meta-analyses by means of a Bayesian approach to determinate possible false report associations. A systematic search was performed for meta-analyses with associations between gene polymorphisms in interleukins and CP. The calculations for the False-Positive Rate Probability (FPRP) and the Bayesian False Discovery Probability (BFDP) were performed to assess the noteworthiness with a statistical power of 1.2 and 1.5 of Odds Ratio at a prior probability of 10-3 and 10-6. As results, eight meta-analyses approaching the IL1A/rs1800587, IL1B/rs1143634, IL1RN/rs2234663, IL4/rs2243250, IL6/rs1800795/rs1800796, IL17A/rs2275913 and IL18/rs1946518/rs187238 polymorphisms have been identified. Twenty-two from 270 calculations (8.15%) were noteworthy. Herein, we have identified the IL1A and IL1B polymorphisms as noteworthy biomarkers for CP susceptibility.-
dc.description.statementOfResponsibilityrestriction-
dc.languageCYTOKINE-
dc.publisherCYTOKINE-
dc.relation.isPartOfCYTOKINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePolymorphisms in the interleukin genes and chronic periodontitis: A field synopsis and revaluation by Bayesian approaches-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorFelipe Rodolfo Pereira da Silva-
dc.contributor.googleauthorLarissa Dos Santos Pessoa-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorEven Herlany Pereira Alves-
dc.contributor.googleauthorReyce Santos Koga-
dc.contributor.googleauthorCamila Valente Smith-
dc.contributor.googleauthorDaniel Fernando Pereira Vasconcelos-
dc.contributor.googleauthorAnna Carolina Toledo da Cunha Pereira-
dc.identifier.doi10.1016/j.cyto.2020.155361-
dc.contributor.localIdA02142-
dc.relation.journalcodeJ00691-
dc.identifier.eissn1096-0023-
dc.identifier.pmid33223448-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S104346662030377-
dc.subject.keywordAlleles-
dc.subject.keywordGenetic variations-
dc.subject.keywordOdds ratio-
dc.subject.keywordPeriodontal diseases-
dc.subject.keywordRisk factors-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.citation.volume138-
dc.citation.startPage155361-
dc.identifier.bibliographicCitationCYTOKINE, Vol.138 : 155361, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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