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Clinicopathologic and MRI features of combined hepatocellular-cholangiocarcinoma in patients with or without cirrhosis
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 이선영 | - |
dc.date.accessioned | 2021-09-29T00:56:47Z | - |
dc.date.available | 2021-09-29T00:56:47Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184117 | - |
dc.description.abstract | Background and aims: Differences in combined hepatocellular-cholangiocarcinomas (cHCC-CCAs) arising in high-risk patients with or without liver cirrhosis have not been elucidated. This study aimed to compare the clinicopathologic and imaging characteristics of cHCC-CCAs in patients with or without cirrhosis and to determine the prognostic factors for recurrence-free survival (RFS) after curative resections of single cHCC-CCAs. Methods: This retrospective study included 113 patients with surgically resected single cHCC-CCAs who underwent preoperative magnetic resonance imaging from January 2008 to December 2019 at two tertiary referral centres. Clinical, pathologic and imaging features of tumours were compared in high-risk patients with or without cirrhosis. Imaging features were assessed using the Liver Imaging Reporting and Data System (LI-RADS) version 2018. RFS and associated factors were evaluated using Cox proportional hazards regression analysis, Kaplan-Meier analysis and log-rank test. Results: cHCC-CCAs arising from cirrhotic livers had a smaller mean tumour size (2.9 cm vs. 4.5 cm; P < .001) and were more frequently categorized as LR-5 or 4 (41.2% vs. 20.0%; P = .024) than those arising from non-cirrhotic livers. In multivariable analysis, a tumour size of > 3 cm (hazard ratio [HR], 2.081; 95% confidence interval [CI], 1.180-3.668; P = .011) and the LR-M category (HR, 2.302; 95% CI, 1.198-4.424; P = .012) were independent predictors associated with worse RFS. Conclusions: The tumour size and distribution of LI-RADS categories of cHCC-CCAs differed in high-risk patients with or without cirrhosis. And LR-M category was a worse prognosis predictor after curative resections than LR-5 or 4 category. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bile Duct Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Bile Duct Neoplasms* / surgery | - |
dc.subject.MESH | Bile Ducts, Intrahepatic | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnostic imaging | - |
dc.subject.MESH | Cholangiocarcinoma* / diagnostic imaging | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis / diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Clinicopathologic and MRI features of combined hepatocellular-cholangiocarcinoma in patients with or without cirrhosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Jongjin Yoon | - |
dc.contributor.googleauthor | Jeong A Hwang | - |
dc.contributor.googleauthor | Sunyoung Lee | - |
dc.contributor.googleauthor | Ji E Lee | - |
dc.contributor.googleauthor | Sang Y Ha | - |
dc.contributor.googleauthor | Young N Park | - |
dc.identifier.doi | 10.1111/liv.14798 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A05659 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 33503328 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/liv.14798 | - |
dc.subject.keyword | cirrhosis | - |
dc.subject.keyword | combined hepatocellular-cholangiocarcinoma | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 이선영 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1641 | - |
dc.citation.endPage | 1651 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.41(7) : 1641-1651, 2021-07 | - |
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