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Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

Authors
 Woojin Choi  ;  Sohyeon Park  ;  Jae-Sung Kwon  ;  Eun-Young Jang  ;  Ji-Yeong Kim  ;  Jiwoong Heo  ;  YoungDeok Hwang  ;  Byeong-Su Kim  ;  Ji-Hoi Moon  ;  Sungwon Jung  ;  Sung-Hwan Choi  ;  Hwankyu Lee  ;  Hyo-Won Ahn  ;  Jinkee Hong 
Citation
 ACS NANO, Vol.15(4) : 6811-6828, 2021-04 
Journal Title
ACS NANO
ISSN
 1936-0851 
Issue Date
2021-04
MeSH
Polyelectrolytes ; Polymers*
Keywords
antipolyelectrolyte effect ; implantable biomedical device ; in vivo antifouling ; polymer science ; zwitterionic polymer
Abstract
Zwitterionic polymers have extraordinary properties, that is, significant hydration and the so-called antipolyelectrolyte effect, which make them suitable for biomedical applications. The hydration induces an antifouling effect, and this has been investigated significantly. The antipolyelectrolyte effect refers to the extraordinary ion-responsive behavior of particular polymers that swell and hydrate considerably in physiological solutions. This actuation begins to attract attention to achieve in vivo antifouling that is challenging for general polyelectrolytes. In this study, we established the sophisticated cornerstone of the antipolyelectrolyte effect in detail, including (i) the essential parameters, (ii) experimental verifications, and (iii) effect of improving antifouling performance. First, we find that both osmotic force and charge screening are essential factors. Second, we identify the antipolyelectrolyte effect by visualizing the swelling and hydration dynamics. Finally, we verify that the antifouling performance can be enhanced by exploiting the antipolyelectrolyte effect and report reduction of 85% and 80% in ex and in vivo biofilm formation, respectively.
Full Text
https://pubs.acs.org/doi/10.1021/acsnano.0c10431
DOI
10.1021/acsnano.0c10431
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184072
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