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D-dimer predicts poor hospitalisation outcomes in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis

Authors
 Jung Yoon Pyo  ;  Byoungwoo Yoo  ;  Minkyung Kwon  ;  William Han Bae  ;  Se Jin Byun  ;  Sang-Won Lee  ;  Yong-Beom Park  ;  Jason Jungsik Song 
Citation
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.39 Supple 129(2) : S94-S100, 2021-03 
Journal Title
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
ISSN
 0392-856X 
Issue Date
2021-03
MeSH
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / diagnosis ; Fibrin Fibrinogen Degradation Products ; Hospitalization ; Humans ; Republic of Korea / epidemiology ; Retrospective Studies ; Seoul
Abstract
Objectives: The in-hospital mortality rate among patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is high. Unfortunately, there is no reliable prognostic biomarker. This study aimed to investigate whether elevated D-dimer levels can predict hospitalisation outcomes among patients with AAV.

Methods: We performed a retrospective analysis at a tertiary medical centre in Seoul, South Korea, between 2005 and 2019. Patients with AAV requiring hospitalisation, whose D-dimer levels were available within one week of hospitalisation, were included; patients with known alternative reasons for elevated D-dimer were excluded. Death and intensive care unit requirements were defined as adverse outcomes.

Results: In total, 61 AAV patients with a total of 100 episodes of hospitalisation were included. Median D-dimer levels were significantly higher in patients with adverse outcomes than in those without adverse outcomes (1.84 vs. 0.42 mg/dL; p=0.006). Consistently, the incidence of the adverse outcomes was significantly higher in the high D-dimer group (≥0.699 mg/dL; n = 40) than in the low D-dimer group (<0.699 mg/dL; n = 60) (35% vs. 10%; p=0.002). Multivariate logistic regression analysis revealed that a high D-dimer level was a significant risk factor for adverse outcomes (hazard ratio, 4.852; 95% confidence interval, 1.320-17.833; p=0.017). Kaplan-Meier survival analysis revealed that the high D-dimer group was associated with more 30-day in-hospital adverse outcomes than the low D-dimer group (p=0.008).

Conclusions: High D-dimer levels on admission are significantly associated with adverse outcomes among patients with AAV.
Full Text
https://www.clinexprheumatol.org/abstract.asp?a=16121
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Byun, Se Jin(변세진)
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Yoo, Byung Woo(유병우)
Lee, Sang-Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Pyo, Jung Yoon(표정윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184058
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