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D-dimer predicts poor hospitalisation outcomes in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis

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dc.contributor.author박용범-
dc.contributor.author변세진-
dc.contributor.author송정식-
dc.contributor.author유병우-
dc.contributor.author이상원-
dc.contributor.author표정윤-
dc.contributor.author변세진-
dc.contributor.author송정식-
dc.contributor.author유병우-
dc.contributor.author이상원-
dc.contributor.author표정윤-
dc.date.accessioned2021-09-29T00:49:47Z-
dc.date.available2021-09-29T00:49:47Z-
dc.date.issued2021-03-
dc.identifier.issn0392-856X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184058-
dc.description.abstractObjectives: The in-hospital mortality rate among patients with antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is high. Unfortunately, there is no reliable prognostic biomarker. This study aimed to investigate whether elevated D-dimer levels can predict hospitalisation outcomes among patients with AAV. Methods: We performed a retrospective analysis at a tertiary medical centre in Seoul, South Korea, between 2005 and 2019. Patients with AAV requiring hospitalisation, whose D-dimer levels were available within one week of hospitalisation, were included; patients with known alternative reasons for elevated D-dimer were excluded. Death and intensive care unit requirements were defined as adverse outcomes. Results: In total, 61 AAV patients with a total of 100 episodes of hospitalisation were included. Median D-dimer levels were significantly higher in patients with adverse outcomes than in those without adverse outcomes (1.84 vs. 0.42 mg/dL; p=0.006). Consistently, the incidence of the adverse outcomes was significantly higher in the high D-dimer group (≥0.699 mg/dL; n = 40) than in the low D-dimer group (<0.699 mg/dL; n = 60) (35% vs. 10%; p=0.002). Multivariate logistic regression analysis revealed that a high D-dimer level was a significant risk factor for adverse outcomes (hazard ratio, 4.852; 95% confidence interval, 1.320-17.833; p=0.017). Kaplan-Meier survival analysis revealed that the high D-dimer group was associated with more 30-day in-hospital adverse outcomes than the low D-dimer group (p=0.008). Conclusions: High D-dimer levels on admission are significantly associated with adverse outcomes among patients with AAV.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherClinical And Experimental Rheumatology S.A.S-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / diagnosis-
dc.subject.MESHFibrin Fibrinogen Degradation Products-
dc.subject.MESHHospitalization-
dc.subject.MESHHumans-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeoul-
dc.titleD-dimer predicts poor hospitalisation outcomes in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorByoungwoo Yoo-
dc.contributor.googleauthorMinkyung Kwon-
dc.contributor.googleauthorWilliam Han Bae-
dc.contributor.googleauthorSe Jin Byun-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.localIdA01579-
dc.contributor.localIdA04953-
dc.contributor.localIdA02057-
dc.contributor.localIdA02467-
dc.contributor.localIdA02824-
dc.contributor.localIdA04244-
dc.contributor.localIdA04953-
dc.contributor.localIdA02057-
dc.contributor.localIdA02467-
dc.contributor.localIdA02824-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ00555-
dc.identifier.eissn1593-098X-
dc.identifier.pmid33635209-
dc.identifier.urlhttps://www.clinexprheumatol.org/abstract.asp?a=16121-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor변세진-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor유병우-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor표정윤-
dc.contributor.affiliatedAuthor변세진-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor유병우-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume39 Supple 129-
dc.citation.number2-
dc.citation.startPageS94-
dc.citation.endPageS100-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.39 Supple 129(2) : S94-S100, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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