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Computed Tomography-Derived Skeletal Muscle Radiodensity Predicts Peak Weight-Corrected Jump Power in Older Adults: The Korean Urban Rural Elderly (KURE) Study
DC Field | Value | Language |
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dc.contributor.author | 김창오 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 최진영 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2021-09-29T00:47:36Z | - |
dc.date.available | 2021-09-29T00:47:36Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0171-967X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184037 | - |
dc.description.abstract | Computed tomography (CT)-derived skeletal muscle area (SMA) and skeletal muscle radiodensity (SMD) reflect distinctive quantitative and qualitative characteristics of skeletal muscles. However, data on whether CT-based muscle parameters, especially SMD, can predict muscle function is limited. In a prospective cohort, 1523 community-dwelling older adults who underwent abdominal CT scans and the countermovement two-legged jumping test on a ground reaction force platform were analyzed (mean age 74.7 years, 65.1% women). SMA and SMD were measured at third lumbar vertebra level (L3). Individuals with low jump power (peak weight-corrected jump power < 23.8 W/kg in men and < 19.0 W/kg in women using clinically validated threshold) were older; had lower SMA, SMD, and maximal grip strength values; and had lower chair rise test and timed up and go test performance than those without low jump power. SMD was positively associated with peak weight-corrected jump power (adjusted β = 0.33 and 0.23 per 1 HU increase in men and women, respectively, p < 0.001). One HU decrement in SMD was associated with 10% elevated odds of low jump power (adjusted OR [aOR] 1.10, p < 0.001) after adjusting for age, sex, height, inflammation, and insulin resistance markers, whereas the association of SMA with low jump power was attenuated (aOR 1.00, p = 0.721). SMD showed better discrimination for low jump power than SMA (AUC 0.699 vs. 0.617, p < 0.001), with additional improvement when added to SMA and conventional risk factors (AUC 0.745 to 0.773, p < 0.001). Therefore, CT-measured L3 SMD can be a sensitive surrogate marker for muscle function along with SMA in older adults, which merits further investigation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | CALCIFIED TISSUE INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Computed Tomography-Derived Skeletal Muscle Radiodensity Predicts Peak Weight-Corrected Jump Power in Older Adults: The Korean Urban Rural Elderly (KURE) Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Heewon Choi | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Narae Park | - |
dc.contributor.googleauthor | Chang Oh Kim | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Jin Young Choi | - |
dc.contributor.googleauthor | Yoosik Youm | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1007/s00223-021-00812-9 | - |
dc.contributor.localId | A01044 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A04200 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00425 | - |
dc.identifier.eissn | 1432-0827 | - |
dc.identifier.pmid | 33566115 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00223-021-00812-9 | - |
dc.subject.keyword | Aging | - |
dc.subject.keyword | Muscle density | - |
dc.subject.keyword | Muscle mass | - |
dc.subject.keyword | Muscle radiation attenuation | - |
dc.subject.keyword | Myosteatosis | - |
dc.subject.keyword | Physical performance | - |
dc.contributor.alternativeName | Kim, Chang Oh | - |
dc.contributor.affiliatedAuthor | 김창오 | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 최진영 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.citation.volume | 108 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 764 | - |
dc.citation.endPage | 774 | - |
dc.identifier.bibliographicCitation | CALCIFIED TISSUE INTERNATIONAL, Vol.108(6) : 764-774, 2021-06 | - |
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