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Use of Autologous Adipose-Derived Stromal Vascular Fractions in Revision Rhinoplasty for Severe Contractures in Asian Patients

Authors
 Tae Hwan Ahn  ;  Won Lee  ;  Hyoung Moon Kim  ;  Sung Bin Cho  ;  Eun-Jung Yang 
Citation
 PLASTIC AND RECONSTRUCTIVE SURGERY, Vol.147(3) : 401e-411e, 2021-03 
Journal Title
PLASTIC AND RECONSTRUCTIVE SURGERY
ISSN
 0032-1052 
Issue Date
2021-03
Abstract
Background: Autologous adipose-derived stromal vascular fraction treatments have been shown to elicit antiinflammatory, antifibrotic, immunomodulatory, angiogenic, and regenerative effects. Injections of adipose-derived stromal vascular fraction have been used to treat severely scarred tissues.

Methods: Revision septorhinoplasty was performed in 40 patients with severely contracted noses. Clinical outcomes and adverse events were compared between one group of patients treated with adjuvant adipose-derived stromal vascular fraction injections and a control group of patients treated with adjuvant 0.9% preservative-free saline injections.

Results: In the adipose-derived stromal vascular fraction group, nasal lengths were estimated at 4.2 ± 0.2 cm at baseline to 5.1 ± 0.2 cm at 18 months after revision septorhinoplasty. The lengths of nasal tip projection improved from 2.2 ± 0.2 cm at baseline to 2.9 ± 0.1 cm 18 months after surgery. In addition, nasofrontal angles improved from 125.6 ± 5.1 degrees at baseline to 128.1 ± 4.8 degrees 18 months after surgery. Nasolabial angles in the adipose-derived stromal vascular fraction group were estimated at 105.8 ± 6.5 degrees at baseline and 94.9 ± 5.6 degrees 18 months after surgery. Of these, nasal length, nasal tip projection, and nasolabial angle, but not nasofrontal angle, values improved more in the adipose-derived stromal vascular fraction group than in the control group.

Conclusion: Preoperative and postoperative adjuvant adipose-derived stromal vascular fraction treatment markedly improved the therapeutic outcomes of revision rhinoseptoplasty of severely contracted noses without major side effects.
Full Text
https://journals.lww.com/plasreconsurg/Fulltext/2021/03000/Use_of_Autologous_Adipose_Derived_Stromal_Vascular.10.aspx
DOI
10.1097/PRS.0000000000007623
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Yang, Eun-Jung(양은정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184004
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