Cited 31 times in
Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김윤중 | - |
dc.contributor.author | 박예원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 홍지만 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2021-09-29T00:39:38Z | - |
dc.date.available | 2021-09-29T00:39:38Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183974 | - |
dc.description.abstract | Objective: To investigate the association between enlarged perivascular spaces (PVS) in the basal ganglia (BG-PVS) and long-term motor outcomes in Parkinson disease (PD). Methods: We reviewed the medical records of 248 patients with drug-naive early-stage PD (follow-up >3 years, mean age 67.44 ± 8.46 years, 130 female) who underwent brain MRI and dopamine transporter (DAT) scans at initial assessment. The number of baseline enlarged BG-PVS was counted on axial T2-weighted images. Then, patients were divided into 2 groups: a PD group with a low number (0-10) of enlarged PVS (PD-EPVS-; n = 156) and a PD group with a high number (>10) of enlarged PVS (PD-EPVS+; n = 92). We used Cox regression models to compare the levodopa-induced dyskinesia (LID)-, wearing-off-, and freezing of gait (FOG)-free times between groups. We also compared longitudinal increases in levodopa-equivalent dose per body weight between groups using a linear mixed model. Results: Patients in the PD-EPVS+ group were older (72.28 ± 6.07 years) and had greater small vessel disease burden than those in the PD-EPVS- group (64.58 ± 8.38 years). The PD-EPVS+ group exhibited more severely decreased DAT availability in all striatal subregions except the ventral striatum. The risk of FOG was higher in the PD-EPVS+ group, but the risk of LID or wearing-off was comparable between groups. The PD-EPVS+ group required higher doses of dopaminergic medications for effective symptom control compared to the PD-EPVS- group. Conclusion: This study suggests that baseline enlarged BG-PVS can be an indicator of the progression of motor disability in PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Basal Ganglia / pathology* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glymphatic System / pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Motor Disorders / etiology | - |
dc.subject.MESH | Motor Disorders / pathology | - |
dc.subject.MESH | Parkinson Disease / complications | - |
dc.subject.MESH | Parkinson Disease / pathology* | - |
dc.subject.MESH | Prognosis | - |
dc.title | Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Na-Young Shin | - |
dc.contributor.googleauthor | Yae Won Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Ji-Man Hong | - |
dc.contributor.googleauthor | Yun Joong Kim | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.identifier.doi | 10.1212/WNL.0000000000011797 | - |
dc.contributor.localId | A00796 | - |
dc.contributor.localId | A05330 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.contributor.localId | A04439 | - |
dc.relation.journalcode | J02340 | - |
dc.identifier.eissn | 1526-632X | - |
dc.identifier.pmid | 33653906 | - |
dc.identifier.url | https://n.neurology.org/content/96/16/e2121.long | - |
dc.contributor.alternativeName | Kim, Yun Joong | - |
dc.contributor.affiliatedAuthor | 김윤중 | - |
dc.contributor.affiliatedAuthor | 박예원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.contributor.affiliatedAuthor | 홍지만 | - |
dc.citation.volume | 96 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | e2121 | - |
dc.citation.endPage | e2131 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, Vol.96(16) : e2121-e2131, 2021-04 | - |
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