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Microstructural Connectivity is More Related to Cognition than Conventional MRI in Parkinson's Disease

Authors
 Yang Hyun Lee  ;  Wha Jin Lee  ;  Seok Jong Chung  ;  Han Soo Yoo  ;  Jin Ho Jung  ;  Kyoungwon Baik  ;  Young H Sohn  ;  Joon-Kyung Seong  ;  Phil Hyu Lee 
Citation
 JOURNAL OF PARKINSONS DISEASE, Vol.11(1) : 239-249, 2021-02 
Journal Title
JOURNAL OF PARKINSONS DISEASE
ISSN
 1877-7171 
Issue Date
2021-02
Keywords
Cognition ; Parkinson’s disease ; diffusion tensor imaging ; microstructural connectivity ; white matter hyperintensities
Abstract
Background: The different effects of white matter hyperintensity (WMH) severity and WMH-associated microstructural connectivity on cognition in the early stages of Parkinson's disease (PD) have not been investigated.

Objective: To investigate the differential effect of WMH severity and WMH-associated microstructural connectivity on cognition in early stages of PD.

Methods: A total of 136 de novo PD patients were enrolled and divided into groups based on total WMH visual rating scores as follows: mild, moderate, and severe. Microstructural connectivity was measured using graph theoretical analysis according to WMH severity. Additionally, correlation coefficients between WMH-associated microstructural connectivity or WMH scores and cognitive performance were assessed.

Results: Patients with severe WMHs demonstrated poorer performance in language function than those with moderate WMHs, and in frontal/executive and visual memory function than those with mild WMHs. Areas of microstructural connectivity were more extensive in patients with severe WMHs compared to those with mild and moderate WMHs, involving frontal and parieto-temporal regions. WMH-associated right fronto-temporo-parietal microstructural disintegration was correlated with cognitive dysfunction in attention, frontal/executive, and memory domains, whereas there was no correlation between WMH scores and any cognitive domains.

Conclusion: These data suggest that disruption of microstructural networks by WMHs, rather than WMH burden itself, contributed more to cognitive impairment in PD.
Full Text
https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd202312
DOI
10.3233/JPD-202312
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183968
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