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Immune-modulating Effect of Korean Red Ginseng by Balancing the Ratio of Peripheral T Lymphocytes in Bile Duct or Pancreatic Cancer Patients With Adjuvant Chemotherapy

Authors
 Im-Kyung Kim  ;  Kang Young Lee  ;  Jeonghyun Kang  ;  Joon Seong Park  ;  Joon Jeong 
Citation
 IN VIVO, Vol.35(3) : 1895-1900, 2021-06 
Journal Title
IN VIVO
ISSN
 0258-851X 
Issue Date
2021-06
MeSH
Bile Ducts ; Chemotherapy, Adjuvant ; Humans ; Panax* ; Pancreatic Neoplasms* / drug therapy ; Prospective Studies
Keywords
Bile duct cancer ; Korean Red ginseng ; chemotherapy ; immune function ; pancreatic cancer
Abstract
Background/aim: We aimed to clarify the clinical effect of Korean Red ginseng administered with adjuvant chemotherapy on the immune function of patients with bile duct or pancreatic cancer.

Patients and methods: This was a prospective, randomized controlled trial conducted at a single tertiary center. Twenty-six consecutive patients who underwent curative resection for bile duct or pancreatic cancer followed by 5-fluorouracil/leucovorin or gemcitabine chemotherapy were included. They were randomized 1:1 to the ginseng and control groups. Immune and inflammatory markers were assayed in peripheral blood samples during and after chemotherapy.

Results: Intergroup differences in immune-related parameters before and during chemotherapy were not significant. After chemotherapy, the percentage of CD4+ T lymphocytes was significantly higher in the ginseng group than in the control group (42.01% vs. 33.69%, p=0.048). The ratio of CD4+/CD8+ T lymphocytes was also higher in the ginseng group (2.03 vs. 1.28, p=0.027). Neutropenia and liver dysfunction prevalence did not differ between the groups.

Conclusion: The ginseng group, which received Korean Red ginseng daily during adjuvant chemotherapy, showed higher levels of CD4+ T lymphocytes and CD4+/CD8+ T lymphocyte ratio after chemotherapy.
Files in This Item:
T202101542.pdf Download
DOI
10.21873/invivo.12454
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jeonghyun(강정현) ORCID logo https://orcid.org/0000-0001-7311-6053
Kim, Im Kyung(김임경) ORCID logo https://orcid.org/0000-0001-8505-5307
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Lee, Kang Young(이강영)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183961
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