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Immune-modulating Effect of Korean Red Ginseng by Balancing the Ratio of Peripheral T Lymphocytes in Bile Duct or Pancreatic Cancer Patients With Adjuvant Chemotherapy
DC Field | Value | Language |
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dc.contributor.author | 강정현 | - |
dc.contributor.author | 김임경 | - |
dc.contributor.author | 박준성 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2021-09-29T00:37:30Z | - |
dc.date.available | 2021-09-29T00:37:30Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183961 | - |
dc.description.abstract | Background/aim: We aimed to clarify the clinical effect of Korean Red ginseng administered with adjuvant chemotherapy on the immune function of patients with bile duct or pancreatic cancer. Patients and methods: This was a prospective, randomized controlled trial conducted at a single tertiary center. Twenty-six consecutive patients who underwent curative resection for bile duct or pancreatic cancer followed by 5-fluorouracil/leucovorin or gemcitabine chemotherapy were included. They were randomized 1:1 to the ginseng and control groups. Immune and inflammatory markers were assayed in peripheral blood samples during and after chemotherapy. Results: Intergroup differences in immune-related parameters before and during chemotherapy were not significant. After chemotherapy, the percentage of CD4+ T lymphocytes was significantly higher in the ginseng group than in the control group (42.01% vs. 33.69%, p=0.048). The ratio of CD4+/CD8+ T lymphocytes was also higher in the ginseng group (2.03 vs. 1.28, p=0.027). Neutropenia and liver dysfunction prevalence did not differ between the groups. Conclusion: The ginseng group, which received Korean Red ginseng daily during adjuvant chemotherapy, showed higher levels of CD4+ T lymphocytes and CD4+/CD8+ T lymphocyte ratio after chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Delinassios | - |
dc.relation.isPartOf | IN VIVO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bile Ducts | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Panax* | - |
dc.subject.MESH | Pancreatic Neoplasms* / drug therapy | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Immune-modulating Effect of Korean Red Ginseng by Balancing the Ratio of Peripheral T Lymphocytes in Bile Duct or Pancreatic Cancer Patients With Adjuvant Chemotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Im-Kyung Kim | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Jeonghyun Kang | - |
dc.contributor.googleauthor | Joon Seong Park | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.identifier.doi | 10.21873/invivo.12454 | - |
dc.contributor.localId | A00080 | - |
dc.contributor.localId | A00851 | - |
dc.contributor.localId | A01672 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J01043 | - |
dc.identifier.eissn | 1791-7549 | - |
dc.identifier.pmid | 33910879 | - |
dc.subject.keyword | Bile duct cancer | - |
dc.subject.keyword | Korean Red ginseng | - |
dc.subject.keyword | chemotherapy | - |
dc.subject.keyword | immune function | - |
dc.subject.keyword | pancreatic cancer | - |
dc.contributor.alternativeName | Kang, Jeonghyun | - |
dc.contributor.affiliatedAuthor | 강정현 | - |
dc.contributor.affiliatedAuthor | 김임경 | - |
dc.contributor.affiliatedAuthor | 박준성 | - |
dc.contributor.affiliatedAuthor | 이강영 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1895 | - |
dc.citation.endPage | 1900 | - |
dc.identifier.bibliographicCitation | IN VIVO, Vol.35(3) : 1895-1900, 2021-06 | - |
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