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Concordance of Three Automated Procalcitonin Immunoassays at Medical Decision Points

Authors
 Hae Weon Cho  ;  Sun Hee Kim  ;  Yonggeun Cho  ;  Seok Hoon Jeong  ;  Sang-Guk Lee 
Citation
 ANNALS OF LABORATORY MEDICINE, Vol.41(4) : 419-423, 2021-07 
Journal Title
ANNALS OF LABORATORY MEDICINE
ISSN
 2234-3806 
Issue Date
2021-07
Keywords
Atellica IM 1600 ; Cobas e801 ; Concordance ; Immunoassay ; Kryptor ; Procalcitonin ; Standardization
Abstract
Procalcitonin (PCT) is a useful bacterial infection biomarker with the potential for guiding antibiotic therapy. We evaluated the concordance of three automated PCT immunoassays: Kryptor (BRAHMS GmbH, Hennigsdorf, Germany), Atellica IM 1600 (Siemens Healthcare Diagnostics, Munich, Germany), and Cobas e801 (Roche Diagnostics, Mannheim, Germany). In 119 serum samples with a PCT concentration <5.00 μg/L, Kryptor (reference assay) was compared with the other two immunoassays by Spearman's rank correlation, regression analysis, and concordance at two antibiotic stewardship medical decision points: 0.25 and 0.50 μg/L. The Atellica IM 1600 and Cobas e801 results showed high correlations with those of Kryptor, with correlation coefficient (ρ) values of 0.97 and 0.99, respectively. However, negative biases were observed in both immunoassays (slope/y-intercept: 0.75/-0.00 for Atellica IM 1600; 0.88/-0.01 for Cobas e801). Atellica IM 1600 and Cobas e801 demonstrated excellent concordance with Kryptor at both medical decision points, with linearly weighted κ values of 0.90 and 0.92, respectively, despite discrepancies, which were more prominent at the 0.25 μg/L medical decision point. Based on these biases and discrepancies, the alternate use of different PCT immunoassays in repeat examinations is inadvisable. Standardization is required before comparing the results of different PCT immunoassays.
Files in This Item:
T202101011.pdf Download
DOI
10.3343/alm.2021.41.4.419
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183957
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