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Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma

Authors
 Hong Kwan Kim  ;  Je-Gun Joung  ;  Yoon-La Choi  ;  Se-Hoon Lee  ;  Byung Jo Park  ;  Yong Soo Choi  ;  Daeun Ryu  ;  Jae-Yong Nam  ;  Mi-Sook Lee  ;  Woong-Yang Park  ;  Soohyun Hwang  ;  Hongui Cha  ;  Hong Sook Kim  ;  Sanghyuk Lee  ;  Yeonjoo Jung  ;  Jong Eun Lee  ;  Junsang Doh  ;  Soonmyung Paik  ;  Jung Hee Kang  ;  Jinseon Lee  ;  Jhingook Kim 
Citation
 ISCIENCE, Vol.23(8) : 101386, 2020-08 
Journal Title
ISCIENCE
Issue Date
2020-08
Keywords
Cancer Systems Biology ; Genomics ; Immunology
Abstract
Exome and transcriptome analyses of clinically homogeneous early-stage never-smoker female patients with lung adenocarcinoma were performed to understand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, developing a method for effective selection of rare immune checkpoint blockade responders, and finding new treatment strategies.
Files in This Item:
T202007250.pdf Download
DOI
10.1016/j.isci.2020.101386
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Paik, Soon Myung(백순명) ORCID logo https://orcid.org/0000-0001-9688-6480
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183934
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