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Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 백순명 | - |
dc.date.accessioned | 2021-09-29T00:35:17Z | - |
dc.date.available | 2021-09-29T00:35:17Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183934 | - |
dc.description.abstract | Exome and transcriptome analyses of clinically homogeneous early-stage never-smoker female patients with lung adenocarcinoma were performed to understand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, developing a method for effective selection of rare immune checkpoint blockade responders, and finding new treatment strategies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | ISCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Hong Kwan Kim | - |
dc.contributor.googleauthor | Je-Gun Joung | - |
dc.contributor.googleauthor | Yoon-La Choi | - |
dc.contributor.googleauthor | Se-Hoon Lee | - |
dc.contributor.googleauthor | Byung Jo Park | - |
dc.contributor.googleauthor | Yong Soo Choi | - |
dc.contributor.googleauthor | Daeun Ryu | - |
dc.contributor.googleauthor | Jae-Yong Nam | - |
dc.contributor.googleauthor | Mi-Sook Lee | - |
dc.contributor.googleauthor | Woong-Yang Park | - |
dc.contributor.googleauthor | Soohyun Hwang | - |
dc.contributor.googleauthor | Hongui Cha | - |
dc.contributor.googleauthor | Hong Sook Kim | - |
dc.contributor.googleauthor | Sanghyuk Lee | - |
dc.contributor.googleauthor | Yeonjoo Jung | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Junsang Doh | - |
dc.contributor.googleauthor | Soonmyung Paik | - |
dc.contributor.googleauthor | Jung Hee Kang | - |
dc.contributor.googleauthor | Jinseon Lee | - |
dc.contributor.googleauthor | Jhingook Kim | - |
dc.identifier.doi | 10.1016/j.isci.2020.101386 | - |
dc.contributor.localId | A01823 | - |
dc.relation.journalcode | J03874 | - |
dc.identifier.eissn | 2589-0042 | - |
dc.identifier.pmid | 32795913 | - |
dc.subject.keyword | Cancer Systems Biology | - |
dc.subject.keyword | Genomics | - |
dc.subject.keyword | Immunology | - |
dc.contributor.alternativeName | Paik, Soon Myung | - |
dc.contributor.affiliatedAuthor | 백순명 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 101386 | - |
dc.identifier.bibliographicCitation | ISCIENCE, Vol.23(8) : 101386, 2020-08 | - |
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