Mysathenia gravis is an autoimmune neuromuscular disorder maminfested clinically as weakness and easy fatigability of the skeletal muscle groups. It is caused by interference in the conduction of nerve impulses across the myoneural junction due to antibodies directed against the acetylocholine receptor. During pregnancy, the clinical course of myasthenia gravis is usually not a steady state, and influences of myasthenia gravis on pregnancy outcome is variable. We experienced a patient with myasthenia gravis associated with pregnancy who underwent a vaginal delivery and transient neonatal myasthenia gravis of the newborn. We present this case and with a review of the pertinent literature.