신장이식전 측정한 혈청 IgA 및 IgA - Anti - Fab 자가항체의 정량분석과 그 의의에 관한 예비 연구

Abstract

Recent reports documented an association between the pretransplant serum IgA level and/or IgA-Anti-Fab antibody activity, and the increased graft survival in kidney transplants. This pilot study correlated the serum IgA levels as well as IgA-Anti-Fab antibody activities, with the living donor renal allograft survival. Pretransplant sera of 79 kidney transplants were investigated for IgA level by nephlometry and IgA-Anti-Fab autoantibody by ELISA, together with 18 sera from controls. Patients were divided into 2 cohort groups about the median value of the serum IgA concentration. High IgA levels did correlate with increased graft survival with pretransplant serum IgA level above vs. below the median(352 mg/dl) displaying a 13% survival advantage at 5 years after transplantation. However, pretransplant serum IgA-Anti-Fab activities did not correlate with graft survival with levels above vs. below the median(38 O.D.). In conclusion, this pilot study, although based on the limited numbers of patients, suggest that pretransplant serum IgA level might be a potential candidate for the Prognostic indicator of long-term renal allograft survival. To confirm and extend the power of serum IgA and/or IgA-Anti-Fab antibody, main project based on the large number of patients has be settled down in the near future.