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신장이식전 측정한 혈청 IgA 및 IgA - Anti - Fab 자가항체의 정량분석과 그 의의에 관한 예비 연구

Other Titles
 Pretransplant Serum IgA Concentration and IgA - Anti - Fab Autoantibody Activity in Renal transplant Recipients and their Clinical Significance : A Pilot Study 
 김유선  ;  이정운  ;  김명수  ;  이은미  ;  김현숙  ;  김순일  ;  김택균  ;  박기일 
 Journal of the Korean Society for Transplantation, Vol.10(1) : 187-193, 1996-12 
Journal Title
Journal of the Korean Society for Transplantation(대한이식학회지)
Issue Date
Recent reports documented an association between the pretransplant serum IgA level and/or IgA-Anti-Fab antibody activity, and the increased graft survival in kidney transplants. This pilot study correlated the serum IgA levels as well as IgA-Anti-Fab antibody activities, with the living donor renal allograft survival. Pretransplant sera of 79 kidney transplants were investigated for IgA level by nephlometry and IgA-Anti-Fab autoantibody by ELISA, together with 18 sera from controls. Patients were divided into 2 cohort groups about the median value of the serum IgA concentration. High IgA levels did correlate with increased graft survival with pretransplant serum IgA level above vs. below the median(352 mg/dl) displaying a 13% survival advantage at 5 years after transplantation. However, pretransplant serum IgA-Anti-Fab activities did not correlate with graft survival with levels above vs. below the median(38 O.D.). In conclusion, this pilot study, although based on the limited numbers of patients, suggest that pretransplant serum IgA level might be a potential candidate for the Prognostic indicator of long-term renal allograft survival. To confirm and extend the power of serum IgA and/or IgA-Anti-Fab antibody, main project based on the large number of patients has be settled down in the near future.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
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