토끼에서 음경귀두 체성감각유발전위(SEP)와 조루증 치료제 SS-cream이 미치는 영향

Abstract

The cause of premature ejaculation (PE) has been thought to be psychological in the majority of patients but we have suggested hyperexcitability of the ejaculatory center for an organic basis of premature ejaculation, SS-cream is a topical agent containing 9 oriental herbs for treating PE. Therefore, in order to determine the effects of SS-cream on the excitability of the ejaculation center, we investigated somatosensory evoked potential (SEP) stimulated at glans penis and its effect of SS-cream on rabbits. 30 rabbits were randomly divided into two groups. Group A (n=15) was used as control, and Group B (n=15) was used with the application of SS-cream (0.1gm) on the glans penis. SEP were monitored every 30 minutes in all rabbits. Electrical stimulation was done on the glans penis with surface electrode. The latencies and amplitudes were recorded at Cz and Fz. EEG system. Throughout the studies SEP was reproducible in all rabbit, which were not significantly changed throughout the procedures. The mean latency and amplitude of SEP in control was 20.83 +- 0.79msec and 2.13+-0.10uV. After the topical application of SS-cream on the glans penis, the mean latency was prolonged and the mean amplitude was reduced significantly (p<0.001). With these results, we suggest that SS-cream with the application on the glans penis prolongs the latency and reduces the amplitude from the glans penis in the rabbit, that is, the effect of SS-cream in the treatment of premature ejaculation is testing the ejaculatory reflex from the glans penis