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Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease

Authors
 Hong Kyu Lee  ;  Dong Soo Kim  ;  Geun Woong Noh  ;  Ki Young Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.37(5) : 357-363, 1996-10 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
1996-10
MeSH
Child, Preschool ; Female ; Humans ; Immunoglobulins, Intravenous / therapeutic use* ; Immunophenotyping ; Infant ; Lymphocyte Subsets / immunology* ; Male ; Mucocutaneous Lymph Node Syndrome / immunology ; Mucocutaneous Lymph Node Syndrome / therapy*
Abstract
The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.
Files in This Item:
T199601009.pdf Download
DOI
10.3349/ymj.1996.37.5.357
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183205
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