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Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.date.accessioned | 2021-09-28T07:49:23Z | - |
dc.date.available | 2021-09-28T07:49:23Z | - |
dc.date.issued | 1996-10 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183205 | - |
dc.description.abstract | The effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulins, Intravenous / therapeutic use* | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Lymphocyte Subsets / immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome / immunology | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome / therapy* | - |
dc.title | Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Hong Kyu Lee | - |
dc.contributor.googleauthor | Dong Soo Kim | - |
dc.contributor.googleauthor | Geun Woong Noh | - |
dc.contributor.googleauthor | Ki Young Lee | - |
dc.identifier.doi | 10.3349/ymj.1996.37.5.357 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 8997168 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 357 | - |
dc.citation.endPage | 363 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.37(5) : 357-363, 1996-10 | - |
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