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Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease

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dc.contributor.author김동수-
dc.date.accessioned2021-09-28T07:49:23Z-
dc.date.available2021-09-28T07:49:23Z-
dc.date.issued1996-10-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183205-
dc.description.abstractThe effect of intravenous immune globulin (IVIG) on the lymphocyte phenotypes in acute Kawasaki disease (KD) was studied in a random trial of IVIG-and-aspirin versus aspirin-alone. Before therapy, patients in each treatment group had an increased percentage of B cells, and a decreased percentage of T cells, CD4 T cells, CD8 T cells and CD5+ B cells. There was no significant difference in immunologic parameters between the two groups measured before therapy. Patients treated with IVIG-and-aspirin had by the fourth day developed a highly-significant increase in T cells, CD4 T cells and CD8 T cells and a decrease in B cells. Despite the decrease of B cells, there were significant increases in CD5+ B cells in both treatment groups. However, the degree of increase in the IVIG-and-aspirin treated group was significantly more noticeable than that in the aspirin-alone treated group. These findings indicate that treatment with IVIG restores the T- and B- cell abnormalities, especially CD5+ B-cell abnormalities found in patients with acute KD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHChild, Preschool-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulins, Intravenous / therapeutic use*-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHInfant-
dc.subject.MESHLymphocyte Subsets / immunology*-
dc.subject.MESHMale-
dc.subject.MESHMucocutaneous Lymph Node Syndrome / immunology-
dc.subject.MESHMucocutaneous Lymph Node Syndrome / therapy*-
dc.titleEffects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorHong Kyu Lee-
dc.contributor.googleauthorDong Soo Kim-
dc.contributor.googleauthorGeun Woong Noh-
dc.contributor.googleauthorKi Young Lee-
dc.identifier.doi10.3349/ymj.1996.37.5.357-
dc.contributor.localIdA00405-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid8997168-
dc.contributor.alternativeNameKim, Dong Soo-
dc.contributor.affiliatedAuthor김동수-
dc.citation.volume37-
dc.citation.number5-
dc.citation.startPage357-
dc.citation.endPage363-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.37(5) : 357-363, 1996-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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