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유방암에서 Matrix-metalloproteinase-9(MMP-9)의 발현

Other Titles
 Expression of Matrix-metalloproteinase-9(MMP-9) in Breast Cancer 
Authors
 라선영  ;  김세중  ;  정현철  ;  김주항  ;  노재경  ;  이경식  ;  김병수 
Citation
 Journal of the Korean Cancer Association (대한암학회지), Vol.28(2) : 247-252, 1996-04 
Journal Title
Journal of the Korean Cancer Association(대한암학회지)
ISSN
 0496-6872 
Issue Date
1996-04
Keywords
Breast cancer ; Invasion ; Zymography ; MMP-9
Abstract
The degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical point in tumor invasion and metastasis. We measured the activity of MMP-9 from 28 normal, 12 benign, and 126 breast cancer tissues using gelatin zymography with an image analysis system. Inactive MMP-9 was expressed in 17.5% of the cancer patients compared to 2.5% in 40 non-cancerous tissues(p=0.008). The active form of MMP-9(82kD) was expressed only in T2-T4 stages. During the early phase of breast cancer (DCIS and Tl stage) progression, only the production of inactive MMP-9 was increased. However, as the cancer grew or invaded skin(T2-T4), or with lymphovascular permeation, both production and activation of MMP-9 were increased. In conclusion, MMP-9 productian was the main cause of increased MMP-9 activity during the ear1y phase, while both production and activation were increased in the late phase of breast cancer.
Files in This Item:
T199600945.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183180
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