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유방암에서 Matrix-metalloproteinase-9(MMP-9)의 발현

DC Field Value Language
dc.contributor.author김주항-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author정현철-
dc.date.accessioned2021-09-28T07:47:23Z-
dc.date.available2021-09-28T07:47:23Z-
dc.date.issued1996-04-
dc.identifier.issn0496-6872-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183180-
dc.description.abstractThe degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical point in tumor invasion and metastasis. We measured the activity of MMP-9 from 28 normal, 12 benign, and 126 breast cancer tissues using gelatin zymography with an image analysis system. Inactive MMP-9 was expressed in 17.5% of the cancer patients compared to 2.5% in 40 non-cancerous tissues(p=0.008). The active form of MMP-9(82kD) was expressed only in T2-T4 stages. During the early phase of breast cancer (DCIS and Tl stage) progression, only the production of inactive MMP-9 was increased. However, as the cancer grew or invaded skin(T2-T4), or with lymphovascular permeation, both production and activation of MMP-9 were increased. In conclusion, MMP-9 productian was the main cause of increased MMP-9 activity during the ear1y phase, while both production and activation were increased in the late phase of breast cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한암학회-
dc.relation.isPartOfJournal of the Korean Cancer Association(대한암학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title유방암에서 Matrix-metalloproteinase-9(MMP-9)의 발현-
dc.title.alternativeExpression of Matrix-metalloproteinase-9(MMP-9) in Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthor라선영-
dc.contributor.googleauthor김세중-
dc.contributor.googleauthor정현철-
dc.contributor.googleauthor김주항-
dc.contributor.googleauthor노재경-
dc.contributor.googleauthor이경식-
dc.contributor.googleauthor김병수-
dc.contributor.localIdA00945-
dc.contributor.localIdA01290-
dc.contributor.localIdA01316-
dc.contributor.localIdA03773-
dc.relation.journalcodeJ01813-
dc.subject.keywordBreast cancer-
dc.subject.keywordInvasion-
dc.subject.keywordZymography-
dc.subject.keywordMMP-9-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.affiliatedAuthor김주항-
dc.contributor.affiliatedAuthor노재경-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor정현철-
dc.citation.volume28-
dc.citation.number2-
dc.citation.startPage247-
dc.citation.endPage252-
dc.identifier.bibliographicCitationJournal of the Korean Cancer Association (대한암학회지), Vol.28(2) : 247-252, 1996-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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