Cited 0 times in
유방암에서 Matrix-metalloproteinase-9(MMP-9)의 발현
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주항 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2021-09-28T07:47:23Z | - |
dc.date.available | 2021-09-28T07:47:23Z | - |
dc.date.issued | 1996-04 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183180 | - |
dc.description.abstract | The degradation of the basement membrane by matrix-metalloproteinase(MMP) and serine protease is a critical point in tumor invasion and metastasis. We measured the activity of MMP-9 from 28 normal, 12 benign, and 126 breast cancer tissues using gelatin zymography with an image analysis system. Inactive MMP-9 was expressed in 17.5% of the cancer patients compared to 2.5% in 40 non-cancerous tissues(p=0.008). The active form of MMP-9(82kD) was expressed only in T2-T4 stages. During the early phase of breast cancer (DCIS and Tl stage) progression, only the production of inactive MMP-9 was increased. However, as the cancer grew or invaded skin(T2-T4), or with lymphovascular permeation, both production and activation of MMP-9 were increased. In conclusion, MMP-9 productian was the main cause of increased MMP-9 activity during the ear1y phase, while both production and activation were increased in the late phase of breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association(대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암에서 Matrix-metalloproteinase-9(MMP-9)의 발현 | - |
dc.title.alternative | Expression of Matrix-metalloproteinase-9(MMP-9) in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 라선영 | - |
dc.contributor.googleauthor | 김세중 | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.googleauthor | 김주항 | - |
dc.contributor.googleauthor | 노재경 | - |
dc.contributor.googleauthor | 이경식 | - |
dc.contributor.googleauthor | 김병수 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Invasion | - |
dc.subject.keyword | Zymography | - |
dc.subject.keyword | MMP-9 | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 252 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.28(2) : 247-252, 1996-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.