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신경결찰에 의한 신경병증성 통증 쥐에서 NMDA Antagonist 전처치가 이질통 발생에 미치는 영향

Other Titles
 Effects of Pre-treatment with NMDA Antagonist for Tactile Allodynia in Nerve Ligation Induced Neuropathic Pain Rat 
Authors
 이윤우  ;  윤덕미  ;  이종석  ;  안은경  ;  이영숙  ;  김종래 
Citation
 Korean Journal of Pain (대한통증학회지), Vol.9(2) : 311-317, 1996-11 
Journal Title
Korean Journal of Pain (대한통증학회지)
ISSN
 1226-2579 
Issue Date
1996-11
Keywords
Pain: allodynia ; hyperalgesia ; Drugs: NMDA antagonist ; non-NMDA antagonist ; morphine
Abstract
Background: Following peripheral nerve injury, rats will show a tactile allodynia and hyperalgesia. But the mechanism of allodynia is still obscure. Previous studies have shown this allodynia was reversed by intrathecal alpha-2 agonists and NMDA antagonists, but not by morphine. In formalin test, either the pretreatment of NMDA antagonist or morphine prevents the hyperalgesia. The present studies, using rats rendered allodynic by ligation of the left L5 and L6 nerves, aimed to investigate the effects of pretreatment of MK-801 and morphine on the development of tactile allodynia. Methods and Material: Male Sprague-Dawley rats (100~150g) were anesthetized with halothane, the left L5 and L6 spinal nerves were ligated tightly by 6-0 black silk. For sham operation muscle dissection was performed but the spinal nerve was not ligated. For pretreatment of drugs, MK-801 (NMDA antagonist; 0.3 mg/kg). CNQX (non-NMDA) antagonist; 0.3 mg/kg), morphine (1 mg/kg) or saline (placebo) was administered subcutaneously 30 minutes before operation. A second dose was administered subcutaneously 24 hours after operation and further doses were given daily for 2 days further. The volume of injection was 5 ml/kg. To assess the mechanical allodynia, paw withdrawal thresholds of ipsilateral limb were determined using 8 von Frey hairs. Results: Within 2 days saline, CNQX or morphine injected rats developed tactile allodynia (paw withdrawal threshold was about 2g), and persisted for over 2 weeks. Pretreatment of MK-801 delayed the development of tactile allodynia for 3 days comparing to that of saline injected rat. Conclusion: NMDA receptor in the central nerve system plays an important role in the development of tactile allodynia induced by peripheral nerve injury. But the mechanism may be different from hyperalgesia developed in formalin test.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Duck Mi(윤덕미)
Lee, Youn Woo(이윤우)
Lee, Jong Seok(이종석) ORCID logo https://orcid.org/0000-0002-7945-2530
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183115
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