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Effects of a Nitric Oxide Donor and Nitric Oxide Synthase Inhibitors on Acid Secretion of Isolated Rabbit Gastric Glands

Authors
 Kim H.  ;  Kim K.H. 
Citation
 PHARMACOLOGY, Vol.53(6) : 331-339, 1996-12 
Journal Title
PHARMACOLOGY
ISSN
 0031-7012 
Issue Date
1996-12
MeSH
Animals ; Cyclic AMP / metabolism ; Cyclic GMP / metabolism ; Dose-Response Relationship, Drug ; Gastric Acid / metabolism* ; Gastric Mucosa / drug effects ; Gastric Mucosa / metabolism* ; Histamine / pharmacology* ; Male ; NG-Nitroarginine Methyl Ester ; Nitric Oxide / metabolism ; Nitric Oxide Synthase / antagonists & inhibitors* ; Nitroarginine ; Nitroprusside / pharmacology* ; Rabbits
Abstract
The present study aims to investigate the effect of nitric oxide (NO) on histamine-stimulated acid secretion of gastric glands. An NO donor, sodium nitroprusside (SNP), and inhibitors of NO synthase such as NG-nitro-L-arginine methyl ester (L-NAME) and NG-nitro-L-arginine (L-NNA) with or without L-arginine, a substrate for NO synthase, were added to isolated rabbit gastric glands with the secretagogues. Acid secretion, intracellular concentrations of cGMP and cAMP and lactic dehydrogenase (LDH) release were determined. L-NAME and L-NNA increased stimulated acid secretion, which was reversed by L-arginine. SNP inhibited stimulated acid secretion concentration-dependently; the inhibition was accompanied by an increase in the intracellular cGMP, but neither related to cAMP nor LDH release. In conclusion, NO produced in large quantity by an NO donor inhibits histamine-stimulated acid secretion of isolated rabbit gastric glands.
Full Text
http://www.karger.com/Article/FullText/139448
DOI
10.1159/000139448
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183109
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