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Smoking History and Clinical Features of Cluster Headache: Results from the Korean Cluster Headache Registry

 Pil Wook Chung  ;  Byung Su Kim  ;  Jeong Wook Park  ;  Jong Hee Sohn  ;  Mi Ji Lee  ;  Byung Kun Kim  ;  Min Kyung Chu  ;  Jin Young Ahn  ;  Yun Ju Choi  ;  Tae Jin Song  ;  Dae Woong Bae  ;  Daeyoung Kim  ;  Jae Moon Kim  ;  Soo Kyoung Kim  ;  Kwang Yeol Park  ;  Jae Myun Chung  ;  Heui Soo Moon  ;  Kyungmi Oh  ;  Chin Sang Chung  ;  Soo Jin Cho 
 JOURNAL OF CLINICAL NEUROLOGY, Vol.17(2) : 229-235, 2021-04 
Journal Title
Issue Date
cluster headache ; sex differences ; smoking
Background and purpose: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry. Methods: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. We compared clinical and demographic features between ever-smokers (current or former smokers) and never-smokers. Results: This study enrolled 250 patients who were diagnosed with CH, of which 152 (60.8%) were ever-smokers and 98 (39.2%) were never-smokers. The age at CH onset was significantly lower in the never-smoker group than in the ever-smoker group [27.1±12.9 years vs. 30.6±10.9 years (mean±standard deviation), p=0.024]. Seasonal rhythmicity (58.1% vs. 44.7%, p=0.038) and triptan responsiveness (100% vs. 85.1%, p=0.001) were higher in never-smokers, while other clinical features such as pain severity, duration, attack frequency, and associated autonomic symptoms did not differ significantly between the groups. The male-to-female ratio was markedly higher in ever-smokers (29.4:1) than in never-smokers (1.7:1). Conclusions: Most of the clinical features did not differ significantly between patients with a smoking history and never-smokers. However, the age at CH onset, sex ratio, and seasonal rhythmicity were significantly associated with smoking history.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Chu, Min Kyung(주민경) ORCID logo https://orcid.org/0000-0001-6221-1346
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